miR-421 在胃癌患者诊断中的临床作用：一项荟萃分析。
Clinical role of miR-421 as a novel biomarker in diagnosis of gastric cancer patients: A meta-analysis.
机构信息
Department of General Surgery, Yizheng People's Hospital, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province, China.
Department of Gastrointestinal Surgery, Clinical Medical School of Yangzhou University, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, PR China.
出版信息
Medicine (Baltimore). 2022 May 13;101(19):e29242. doi: 10.1097/MD.0000000000029242.
BACKGROUND
Gastric cancer (GC) has been identified as one of the most common malignancies. It was found that microRNAs can be used as potential biomarkers for GC diagnosis. The aim of this study was to estimate the diagnostic value of 4 potential microRNAs in GC.
METHODS
PubMed, Embase, Cochrane Library, and Web of Science were used to search published studies. The quality of the studies was scored with the Quality Assessment of Diagnostic Accuracy Studies. The pooled sensitivity and specificity, diagnostic odds ratio (DOR) and area under the curve (AUC) were calculated. The heterogeneity was evaluated using Cochrane Q statistics and the inconsistency index.
RESULTS
A total of 22 studies reporting the diagnostic value of miR-21 (n = 9), miR-106 (n = 10), miR-421 (n = 5) and miR-223 (n = 3) were included. Quality Assessment of Diagnostic Accuracy Studies scores showed the high quality of the selected 22 articles. The random effects model was adopted by evaluating the heterogeneity between articles. The DOR, AUC, and Q value of miRNA-21 were 12.37 (95% confidence interval [CI]: 5.36-28.54), 0.86 and 0.79, respectively. The DOR, AUC and Q value of miRNA-106 were 12.98 [95% CI: 7.14-23.61], 0.85 and 0.78, respectively. The DOR, AUC and Q value of miRNA-421 were 27.86 [95% CI: 6.04-128.48], 0.92 and 0.86, respectively. The DOR, AUC and Q value of miRNA-223 were 18.50 [95% CI: 7.80-43.86], 0.87 and 0.80, respectively. These results indicate that miRNA-421 has the highest diagnostic accuracy, followed by miR-223, miRNA-21, and miRNA-106 among the 4 microRNAs in GC.
CONCLUSIONS
miR-21, miR-106, miR-421, and miR-223 have good diagnostic efficacy, especially miR-421, could be used as auxiliary diagnostic indicator for GC.
背景
胃癌（GC）已被确定为最常见的恶性肿瘤之一。已经发现 microRNAs 可以作为 GC 诊断的潜在生物标志物。本研究旨在评估 4 种潜在 microRNAs 在 GC 中的诊断价值。
方法
使用 PubMed、Embase、Cochrane 图书馆和 Web of Science 搜索已发表的研究。使用诊断准确性研究质量评估标准对研究进行质量评分。计算合并的敏感性和特异性、诊断优势比（DOR）和曲线下面积（AUC）。使用 Cochrane Q 统计量和不一致指数评估异质性。
结果
共纳入 22 项研究，报道了 miR-21（n = 9）、miR-106（n = 10）、miR-421（n = 5）和 miR-223（n = 3）的诊断价值。诊断准确性研究质量评估标准评分显示所选 22 篇文章质量较高。通过评估文章之间的异质性，采用了随机效应模型。miR-21 的 DOR、AUC 和 Q 值分别为 12.37（95%置信区间 [CI]：5.36-28.54）、0.86 和 0.79。miR-106 的 DOR、AUC 和 Q 值分别为 12.98[95% CI：7.14-23.61]、0.85 和 0.78。miR-421 的 DOR、AUC 和 Q 值分别为 27.86[95% CI：6.04-128.48]、0.92 和 0.86。miR-223 的 DOR、AUC 和 Q 值分别为 18.50[95% CI：7.80-43.86]、0.87 和 0.80。这些结果表明，miR-421 在 GC 中具有最高的诊断准确性，其次是 miR-223、miR-21 和 miR-106。
结论
miR-21、miR-106、miR-421 和 miR-223 具有良好的诊断效果，尤其是 miR-421，可作为 GC 的辅助诊断指标。
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