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单纯性心脏转位中冠状动脉纽扣转移技术对新主动脉根部大小无影响。

Technique of Coronary Button Transfer Has no Impact on Neoaortic Root Size in Simple Transposition.

机构信息

Heart Centre for Children, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

School of Medicine, The University of Sydney, Sydney, Australia.

出版信息

Semin Thorac Cardiovasc Surg. 2023 Summer;35(2):377-386. doi: 10.1053/j.semtcvs.2022.04.007. Epub 2022 May 15.

Abstract

We studied the effect of various coronary transfer techniques (CTT) on neo-aortic root size after an arterial switch operation (ASO) in simple transposition by excluding the impact of recognized predisposing factors. One hundred and seventy-eight patients with simple transposition were reviewed retrospectively (January 2004-December 2018) and grouped as Punch Hole (n = 83/178), Nonpunch Hole (n = 65/178; Trapdoor or Standard) and Mixed (n = 30/178). Factors predicting the neo-aortic root z-scores- annulus, mid-sinus, and sinotubular junction (STJ) were analyzed by uni/multivariable linear regression. Follow-up was 6 years, Interquartile range (IQR) 3.4,10.6. Preoperative aortic (7.4 mm, IQR 6.9,8) and pulmonary annulus (7.5 mm, IQR 6.8,8.1) sizes were identical (P = 0.831). The changes in preoperative, postoperative, and latest median z-scores for neo-aortic annulus (-0.2, IQR -1.2,0.9; 0.0, IQR -0.9,0.9; 0.9, IQR -0.4,2.6; P < 0.001), mid-sinus (1.1, IQR-0.1,2; 2.6, IQR 1.6,3.7; 2.9, IQR 1.8,4.3; P < 0.001) and STJ (-0.1, IQR -0.8,1.1; 2.1, IQR 0.7,3; 2.4, IQR 1,3.5; P < 0.001) were significant. On multivariate analysis, preoperative pulmonary annulus z-score predicted the latest neo-aortic annulus z-score [Beta estimate (BE) = 0.32, 95% confidence interval (CI) = 0.03,0.62; P = 0.03] and STJ z-score (BE= 0.45, 95% CI= 0.20,0.70; P < 0.0001). CTT did not predict any of the latest neo-aortic z-scores (all P > 0.05). Mild plus neo-aortic regurgitation (neoAR) was not significantly different across CTT groups [punch hole 20% (n = 15/74), mixed 37% (n = 11/30), nonpunch hole 21% (n = 13/62); Fisher-exact P = 0.186], one patient required valve replacement for severe neoAR. The neo-aortic root enlarges significantly over time at all 3 levels following an ASO in simple transposition, however, this is not significantly influenced by the CTT utilized.

摘要

我们研究了在单纯性大动脉转位(ASO)中排除已知易患因素后,不同冠状动脉转移技术(CTT)对新主动脉根部大小的影响。回顾性分析了 2004 年 1 月至 2018 年 12 月期间单纯性大动脉转位的 178 例患者,并分为打孔组(n=83/178)、非打孔组(n=65/178;活瓣或标准)和混合组(n=30/178)。通过单变量/多变量线性回归分析预测新主动脉根部 z 分数-瓣环、中窦和窦管交界处(STJ)的因素。随访 6 年,四分位间距(IQR)为 3.4,10.6。术前主动脉瓣环(7.4mm,IQR 6.9,8)和肺动脉瓣环(7.5mm,IQR 6.8,8.1)大小相同(P=0.831)。新主动脉瓣环(-0.2,IQR-1.2,0.9;0.0,IQR-0.9,0.9;0.9,IQR-0.4,2.6;P<0.001)、中窦(1.1,IQR-0.1,2;2.6,IQR 1.6,3.7;2.9,IQR 1.8,4.3;P<0.001)和 STJ(-0.1,IQR-0.8,1.1;2.1,IQR 0.7,3;2.4,IQR 1,3.5;P<0.001)的术前、术后和最新中位数 z 分数变化有统计学意义。多变量分析显示,术前肺动脉瓣环 z 分数预测了最新的新主动脉瓣环 z 分数[贝塔估计值(BE)=0.32,95%置信区间(CI)=0.03,0.62;P=0.03]和 STJ z 分数(BE=0.45,95%CI=0.20,0.70;P<0.0001)。CTT 不能预测任何最新的新主动脉 z 分数(所有 P>0.05)。轻微的新主动脉瓣反流(neoAR)在 CTT 组之间无显著差异[打孔组 20%(n=15/74),混合组 37%(n=11/30),非打孔组 21%(n=13/62);Fisher 精确检验 P=0.186],1 例患者因严重 neoAR 需要瓣膜置换。单纯性大动脉转位后,新主动脉根部在所有 3 个水平均有显著增大,但这与所采用的 CTT 无显著相关性。

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