Heart Centre for Children, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
School of Medicine, The University of Sydney, Sydney, Australia.
Semin Thorac Cardiovasc Surg. 2023 Summer;35(2):377-386. doi: 10.1053/j.semtcvs.2022.04.007. Epub 2022 May 15.
We studied the effect of various coronary transfer techniques (CTT) on neo-aortic root size after an arterial switch operation (ASO) in simple transposition by excluding the impact of recognized predisposing factors. One hundred and seventy-eight patients with simple transposition were reviewed retrospectively (January 2004-December 2018) and grouped as Punch Hole (n = 83/178), Nonpunch Hole (n = 65/178; Trapdoor or Standard) and Mixed (n = 30/178). Factors predicting the neo-aortic root z-scores- annulus, mid-sinus, and sinotubular junction (STJ) were analyzed by uni/multivariable linear regression. Follow-up was 6 years, Interquartile range (IQR) 3.4,10.6. Preoperative aortic (7.4 mm, IQR 6.9,8) and pulmonary annulus (7.5 mm, IQR 6.8,8.1) sizes were identical (P = 0.831). The changes in preoperative, postoperative, and latest median z-scores for neo-aortic annulus (-0.2, IQR -1.2,0.9; 0.0, IQR -0.9,0.9; 0.9, IQR -0.4,2.6; P < 0.001), mid-sinus (1.1, IQR-0.1,2; 2.6, IQR 1.6,3.7; 2.9, IQR 1.8,4.3; P < 0.001) and STJ (-0.1, IQR -0.8,1.1; 2.1, IQR 0.7,3; 2.4, IQR 1,3.5; P < 0.001) were significant. On multivariate analysis, preoperative pulmonary annulus z-score predicted the latest neo-aortic annulus z-score [Beta estimate (BE) = 0.32, 95% confidence interval (CI) = 0.03,0.62; P = 0.03] and STJ z-score (BE= 0.45, 95% CI= 0.20,0.70; P < 0.0001). CTT did not predict any of the latest neo-aortic z-scores (all P > 0.05). Mild plus neo-aortic regurgitation (neoAR) was not significantly different across CTT groups [punch hole 20% (n = 15/74), mixed 37% (n = 11/30), nonpunch hole 21% (n = 13/62); Fisher-exact P = 0.186], one patient required valve replacement for severe neoAR. The neo-aortic root enlarges significantly over time at all 3 levels following an ASO in simple transposition, however, this is not significantly influenced by the CTT utilized.
我们研究了在单纯性大动脉转位(ASO)中排除已知易患因素后,不同冠状动脉转移技术(CTT)对新主动脉根部大小的影响。回顾性分析了 2004 年 1 月至 2018 年 12 月期间单纯性大动脉转位的 178 例患者,并分为打孔组(n=83/178)、非打孔组(n=65/178;活瓣或标准)和混合组(n=30/178)。通过单变量/多变量线性回归分析预测新主动脉根部 z 分数-瓣环、中窦和窦管交界处(STJ)的因素。随访 6 年,四分位间距(IQR)为 3.4,10.6。术前主动脉瓣环(7.4mm,IQR 6.9,8)和肺动脉瓣环(7.5mm,IQR 6.8,8.1)大小相同(P=0.831)。新主动脉瓣环(-0.2,IQR-1.2,0.9;0.0,IQR-0.9,0.9;0.9,IQR-0.4,2.6;P<0.001)、中窦(1.1,IQR-0.1,2;2.6,IQR 1.6,3.7;2.9,IQR 1.8,4.3;P<0.001)和 STJ(-0.1,IQR-0.8,1.1;2.1,IQR 0.7,3;2.4,IQR 1,3.5;P<0.001)的术前、术后和最新中位数 z 分数变化有统计学意义。多变量分析显示,术前肺动脉瓣环 z 分数预测了最新的新主动脉瓣环 z 分数[贝塔估计值(BE)=0.32,95%置信区间(CI)=0.03,0.62;P=0.03]和 STJ z 分数(BE=0.45,95%CI=0.20,0.70;P<0.0001)。CTT 不能预测任何最新的新主动脉 z 分数(所有 P>0.05)。轻微的新主动脉瓣反流(neoAR)在 CTT 组之间无显著差异[打孔组 20%(n=15/74),混合组 37%(n=11/30),非打孔组 21%(n=13/62);Fisher 精确检验 P=0.186],1 例患者因严重 neoAR 需要瓣膜置换。单纯性大动脉转位后,新主动脉根部在所有 3 个水平均有显著增大,但这与所采用的 CTT 无显著相关性。