From the Division of Pediatric Cardiology (D.M.R., L.Y.T.), Department of Pediatrics, University of Utah, Salt Lake City; United States Air Force (D.M.R.), Washington, DC; and Division of Pediatric Neurology (M.A.W., B.O.), Department of Pediatrics, University of Utah, Salt Lake City.
Neurology. 2022 Jul 11;99(2):73-76. doi: 10.1212/WNL.0000000000200747.
Lambl excrescences are fibrinous connective tissue strands found predominantly on left-sided cardiac valves. These valvular strands are typically benign, but have been implicated as a potential etiology of embolic strokes in adult patients. The significance of Lambl excrescences in pediatric stroke cases is unclear and not previously reported in the literature. In this study, we describe a 10-year-old boy who presented with acute-onset right-sided hemiplegia, found to have multifocal embolic strokes of various ages. Extensive stroke workup was unrevealing, aside from the presence of small, filamentous, strand-like densities associated with the mitral and aortic valves noted on a transesophageal echocardiogram consistent with Lambl excrescences. In this case report, we review Lambl excrescences and their significance in acute stroke and management options for the prevention of future ischemia in these patients.
兰姆波赘生物是主要存在于左侧心脏瓣膜的纤维连接组织索。这些瓣膜索通常是良性的，但已被认为是成年患者栓塞性中风的潜在病因。兰姆波赘生物在儿科中风病例中的意义尚不清楚，以前也没有在文献中报道过。在本研究中，我们描述了一名 10 岁男孩，他因急性发作的右侧偏瘫就诊，发现有多发性不同年龄的栓塞性中风。广泛的中风检查除了在经食管超声心动图上发现与二尖瓣和主动脉瓣相关的小的、丝状、索状密度外，没有发现其他异常，这些密度与兰姆波赘生物一致。在本病例报告中，我们回顾了兰姆波赘生物及其在急性中风中的意义，以及这些患者预防未来缺血的治疗选择。
