Fernandes S, Marques N, Goga L
Division of Neuropsychiatry, Department of Psychiatry, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
S Afr Med J. 2022 Apr 29;112(5):313-316.
SARS-CoV-2 was first identified in Wuhan City, China, in 2019. Initially it was associated with the development of pulmonary disease, but research over the past 2 years has identified effects on multiple systems. Neuropsychiatric manifestations of COVID-19 have been reported in countries around the world, including new-onset psychosis in patients with no personal or family psychiatric history. We present the first case series describing neuropsychiatric manifestations of patients in Johannesburg, South Africa (SA). All four patients presented with their index-episode psychosis, and evidence of COVID-19 infection. The patients had varied psychiatric presentations, from delirium and psychosis to mania, and all responded well to low doses of antipsychotics. One patient had newly diagnosed HIV in addition to COVID-19. Further research is needed to determine the prevalence of neuropsychiatric manifestations in acute SARS-CoV-2 infections in SA.
2019年，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）首次在中国武汉市被发现。最初它与肺部疾病的发展有关，但过去两年的研究发现它对多个系统有影响。世界各地都报告了新冠病毒病（COVID-19）的神经精神表现，包括无个人或家族精神病史的患者出现的新发精神病。我们报告了首个描述南非约翰内斯堡患者神经精神表现的病例系列。所有四名患者均表现为首发精神病性发作，并伴有COVID-19感染的证据。患者的精神症状表现各异，从谵妄、精神病到躁狂，且均对低剂量抗精神病药物反应良好。一名患者除感染COVID-19外，还新诊断出感染了艾滋病毒。需要进一步研究以确定南非急性SARS-CoV-2感染中神经精神表现的患病率。
