分析健康人和蒸发性干眼症参与者的眼表面损伤和炎症迹象的差异。
Analysis of the Differences in Ocular Surface Damage and Inflammatory Signs between Healthy and Evaporative Dry Eye Participants.
机构信息
Departamento de Física Aplicada (Área de Optometría), Facultad de Óptica y Optometría, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
出版信息
Ocul Immunol Inflamm. 2023 Jul;31(5):970-977. doi: 10.1080/09273948.2022.2075398. Epub 2022 May 19.
OBJECTIVE
Distinguish between EDE severity levels by analysing the MGLA, conjunctival hyperemia and corneal staining.
METHODS
One hundred participants were recruited based on OSDI, TO, TFBUT, TMH, and LLP to be categorised as healthy (Group 1) or EDE (Group 2). Group 2 was divided into Group 2A (mild symptoms), 2B (moderate), and 2C (severe). MGLA, conjunctival hyperemia, and corneal staining were measured.
RESULTS
Positive correlation between MGLA, conjunctival hyperemia, and corneal staining were found (all r ≥ 0.221, p ≤ 0.027). Significant differences were found: MGLA between Group 1 vs. 2C and 2C vs. 2A or 2B; conjunctival hyperemia between Group 1 vs. 2A, 2B or 2C; corneal staining between Group 1 vs. 2B or 2C and 2A vs. 2B or 2C (all p ≤ 0.049).
CONCLUSION
Severe EDE participants have higher MGLA, conjunctival hyperemia, and corneal staining values than healthy, mild, or moderate EDE participants.
目的
通过分析 MGLA、结膜充血和角膜染色来区分 EDE 的严重程度。
方法
根据 OSDI、TO、TFBUT、TMH 和 LLP，招募了 100 名参与者，将其分为健康组（第 1 组）或 EDE 组（第 2 组）。第 2 组再分为 2A 组（轻度症状）、2B 组（中度）和 2C 组（重度）。测量 MGLA、结膜充血和角膜染色。
结果
MGLA、结膜充血和角膜染色之间存在正相关（所有 r≥0.221，p≤0.027）。发现了显著差异：MGLA 在第 1 组与第 2C 组和第 2C 组与第 2A 组或 2B 组之间；结膜充血在第 1 组与第 2A 组、2B 组或 2C 组之间；角膜染色在第 1 组与第 2B 组或 2C 组之间，以及第 2A 组与第 2B 组或 2C 组之间（所有 p≤0.049）。
结论
与健康、轻度或中度 EDE 参与者相比，重度 EDE 参与者的 MGLA、结膜充血和角膜染色值更高。
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