GI-2092 - Optometry, Department of Applied Physics (Optometry Area), Universidade de Santiago de Compostela, Campus Vida s/n, Santiago de Compostela, Spain.
Int Ophthalmol. 2023 Jul;43(7):2349-2362. doi: 10.1007/s10792-023-02632-2. Epub 2023 Jan 24.
To determine if the Meibomian Gland (MG) secretion quality is associated with symptoms of ocular discomfort, hours of Video Display Terminals (VDT) use, eyelid margin abnormalities, conjunctival hyperemia, and Meibomian Gland Loss Area (MGLA) in a sample of university students.
An online survey that included an Ocular Surface Disease Index (OSDI) questionnaire and an extra question about hours of VDT use recruited an initial sample of 183 participants. Only 120 participants that fulfilled the inclusion criteria were scheduled for a battery of ocular surface and MG specific exam. The tests include: 1) meibometry, 2) slit lamp exploration of eyelid margin abnormalities (irregularity, hyperemia and MG orifices plugging), MG secretion quality and conjunctival hyperemia, and 3) Meibography.
Significant positive correlations between the MG secretion quality and eyelid margin hyperemia, MG orifices plugging, MGLA, nasal conjunctival hyperemia, and temporal conjunctival hyperemia (Spearman Rho; all r>0.186, p<0.042) were found. Multivariate regression found association between OSDI with hours of VDT use (B=0.316, p=0.007), and eyelid hyperemia (B=0.434, p≤ 0.001). A statistical association between MG secretion quality and eyelid margin hyperemia, MG orifices plugging, MGLA and conjunctival hyperemia (Fisher's exact; all p<0.039) were found. Multivariate regression found association between MG secretion quality with MG orifices plugging (B=0.295, p=0.004) and meibometry (B=-0.001, p=0.029).
Participants with higher values in MG secretion quality have higher values in eyelid margin hyperemia, MG plugging, MGLA, and conjunctival hyperemia. No direct relationship between MG secretion quality and hours of VDT use or OSDI were found.
在大学生样本中，确定睑板腺（MG）分泌物质量是否与眼部不适症状、视频显示终端（VDT）使用时间、睑缘异常、结膜充血和睑板腺缺失区（MGLA）有关。
一项在线调查，包括眼表面疾病指数（OSDI）问卷和一个关于 VDT 使用时间的额外问题，招募了 183 名初步参与者。只有符合纳入标准的 120 名参与者被安排进行一系列眼表面和 MG 特定检查。这些测试包括：1）睑板腺测量，2）裂隙灯检查睑缘异常（不规则、充血和 MG 口堵塞）、MG 分泌质量和结膜充血，以及 3）睑板腺照相。
发现 MG 分泌质量与睑缘充血、MG 口堵塞、MGLA、鼻侧结膜充血和颞侧结膜充血之间存在显著正相关（Spearman Rho；所有 r>0.186，p<0.042）。多元回归发现 OSDI 与 VDT 使用时间（B=0.316，p=0.007）和睑缘充血（B=0.434，p≤0.001）之间存在关联。MG 分泌质量与睑缘充血、MG 口堵塞、MGLA 和结膜充血之间存在统计学关联（Fisher 确切检验；所有 p<0.039）。多元回归发现 MG 分泌质量与 MG 口堵塞（B=0.295，p=0.004）和睑板腺测量（B=-0.001，p=0.029）之间存在关联。
MG 分泌质量较高的参与者，其睑缘充血、MG 堵塞、MGLA 和结膜充血的数值也较高。MG 分泌质量与 VDT 使用时间或 OSDI 之间没有直接关系。
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