Apfelzweig R, Piszkiewicz D, Hooper J A
J Clin Immunol. 1987 Jan;7(1):46-50. doi: 10.1007/BF00915424.
Commercial immune globulins contain varying concentrations of IgA as a minor constituent. For patients who are both IgA deficient and IgA hypersensitive, the administration of most immune globulins is contraindicated due to potentially lethal anaphylactic reactions. We have measured the IgA levels in a broad range of commercial immune globulin preparations by means of a competitive-binding solid-phase radioimmunoassay. Of the products tested, all immune globulins intended for intramuscular administration and most immune globulins for intravenous use had IgA levels of over 150 micrograms/ml. Only two of the intravenous products had IgA concentrations in the range of 10 micrograms/ml or less.
商业免疫球蛋白含有不同浓度的IgA作为次要成分。对于IgA缺乏且对IgA过敏的患者，由于可能发生致命的过敏反应，大多数免疫球蛋白的给药是禁忌的。我们通过竞争性结合固相放射免疫测定法测量了多种商业免疫球蛋白制剂中的IgA水平。在所测试的产品中，所有用于肌肉注射的免疫球蛋白和大多数静脉注射用免疫球蛋白的IgA水平超过150微克/毫升。只有两种静脉注射产品的IgA浓度在10微克/毫升或更低的范围内。
