Department of Microbiology & Immunology, University of Minnesota Medical School, 689 23rd Ave. SE, Minneapolis, MN 55455, USA.
J Med Microbiol. 2022 May;71(5). doi: 10.1099/jmm.0.001505.
is associated with resilient nosocomial infections, with bacteraemia, pneumonia and chronic cystic fibrosis lung infection being the most common clinical presentations. Innate multi-drug resistance and a suite of virulence factors select for infection during long-term antibiotic therapy, contributing to its persistence, treatment recalcitrance, association with poor clinical outcomes and emergence as a problematic pathogen. Horizontal gene transfer and maintenance of large genomes underpin the resilience and cosmopolitan lifestyle of , and complicate its phylogenetic characterization.
与有弹性的医院感染相关,最常见的临床表现是菌血症、肺炎和慢性囊性纤维化肺部感染。固有多重药物耐药性和一系列毒力因子在长期抗生素治疗期间选择 感染,导致其持续存在、治疗难治、与不良临床结局相关以及成为一个有问题的病原体。水平基因转移和大型基因组的维持是 的弹性和世界性生活方式的基础,并使其系统发育特征复杂化。