新生血管性年龄相关性黄斑变性与出血性息肉状脉络膜血管病变患者外周血炎症指标的比较。

Comparison of Peripheral Blood Inflammatory Indices in Patients with Neovascular Age-related Macular Degeneration and Haemorrhagic Polypoidal Choroidal Vasculopathy.

机构信息

Department of Ophthalmology, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, PR China.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.

出版信息

Ocul Immunol Inflamm. 2023 Jul;31(5):935-939. doi: 10.1080/09273948.2022.2071742. Epub 2022 May 19.

DOI:10.1080/09273948.2022.2071742

PMID:35587642

Abstract

PURPOSE

To compare the differences in peripheral blood inflammatory indices between patients with neovascular age-related macular degeneration (nAMD) and haemorrhagic polypoidal choroidal vasculopathy (PCV).

METHODS

Retrospective, best corrected visual acuity (BCVA), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR), were analysed across the nAMD, PCV and normal control (NCG) groups of patients. The ratios' cut-off values for nAMD were calculated.

RESULTS

nAMD had a significantly longer duration and better BCVA than PCV (all P < .05). The NLR, MLR and PLR were significantly higher in nAMD than in PCV and NCG (all P < .01), no significant differences between PCV and NCG (all P > .05). The ROC curve analysis revealed that the cut-off values for NLR and MLR were 1.98 and 0.24, respectively, for nAMD.

CONCLUSION

NLR, MLR and PLR are significantly high in patients with nAMD. The ability of these inflammatory indicators to distinguish nAMD and PCV is unclear.

摘要

目的

比较新生血管性年龄相关性黄斑变性（nAMD）与出血性息肉状脉络膜血管病变（PCV）患者外周血炎症指标的差异。

方法

回顾性分析 nAMD、PCV 和正常对照组（NCG）患者的最佳矫正视力（BCVA）、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和单核细胞与淋巴细胞比值（MLR）。计算 nAMD 的比值截断值。

结果

nAMD 的病程明显长于 PCV，BCVA 明显好于 PCV（均 P <.05）。nAMD 的 NLR、MLR 和 PLR 均明显高于 PCV 和 NCG（均 P <.01），PCV 与 NCG 之间无显著差异（均 P >.05）。ROC 曲线分析显示，NLR 和 MLR 对 nAMD 的截断值分别为 1.98 和 0.24。