Balasch J, Vanrell J A, Creus M, Márquez M, González-Merlo J
Hum Reprod. 1986 Aug;1(5):291-3. doi: 10.1093/oxfordjournals.humrep.a136407.
The luteal phase of 20 infertile women with endometriosis who were treated with danazol (600 mg daily for 6 months) was studied by basal body temperature, plasma progesterone (P), oestradiol (E2) and prolactin (PRL) determination, and endometrial biopsy, in any one of the first three cycles after discontinuation of danazol. All endometrial specimens were noted to be fundal samples and were clearly progestational after danazol therapy. Abnormal secretory phases were detected in three patients, as in the pre-danazol control cycles. Moreover, plasma levels of P, E2 and PRL in post-danazol cycles were similar to those found in control cycles and fell within the normal range in all cases except for one patient having hyperprolactinaemia. In conclusion, our study shows that endometrial inadequacy is not the cause of the increased fetal wastage previously reported among proximally conceived pregnancies after danazol therapy for endometriosis.
对20名患有子宫内膜异位症的不孕女性进行研究，她们在停用达那唑后的前三个周期中的任何一个周期，通过基础体温、血浆孕酮（P）、雌二醇（E2）和催乳素（PRL）测定以及子宫内膜活检，来研究用达那唑（每日600毫克，持续6个月）治疗后的黄体期。所有子宫内膜标本均为宫底样本，达那唑治疗后明显呈孕激素作用。在三名患者中检测到异常分泌期，与达那唑治疗前的对照周期情况相同。此外，达那唑治疗后的周期中，P、E2和PRL的血浆水平与对照周期相似，除一名患有高催乳素血症的患者外，所有病例均在正常范围内。总之，我们的研究表明，子宫内膜功能不全并非先前报道的达那唑治疗子宫内膜异位症后近端受孕妊娠中胎儿丢失增加的原因。
