Wallace A M, Lees D A, Roberts A D, Gray C E, McLaren E H, Low R A
Acta Endocrinol (Copenh). 1984 Dec;107(4):445-9. doi: 10.1530/acta.0.1070445.
A group of 55 women with endometriosis was studied before and during danazol therapy. An unexpectedly high proportion (36%) had a raised serum prolactin level before treatment which was reduced after 50 days of danazol (before treatment 783 +/- 333 mU/l; on danazol 243 +/- 113 mU/l, P less than 0.001). In contrast patients with normal serum prolactin levels showed no significant drop on danazol therapy. In all patients serum oestradiol was significantly reduced during treatment (before treatment 449 +/- 188 pmol/l; on danazol 207 +/- 117 pmol/l, P less than 0.001). In one patient with hyperprolactinaemia danazol reduced both basal and stimulated prolactin levels, whereas in 5 women with normal prolactin levels we could detect no gross alteration in metoclopramide or TRH stimulated prolactin levels associated with danazol therapy. The possibility that normalisation of raised prolactin levels may be secondary to reduced oestrogens and that patients with endometriosis have an increased sensitivity to oestrogen-induced prolactin secretion is discussed.
对55名患有子宫内膜异位症的女性在服用达那唑治疗前及治疗期间进行了研究。治疗前血清催乳素水平升高的比例出人意料地高（36%），服用达那唑50天后有所降低（治疗前783±333 mU/l；服用达那唑时243±113 mU/l，P<0.001）。相比之下，血清催乳素水平正常的患者在服用达那唑治疗后没有显著下降。所有患者在治疗期间血清雌二醇均显著降低（治疗前449±188 pmol/l；服用达那唑时207±117 pmol/l，P<0.001）。在1名高催乳素血症患者中，达那唑降低了基础催乳素水平和刺激后的催乳素水平，而在5名催乳素水平正常的女性中，我们未发现与达那唑治疗相关的甲氧氯普胺或促甲状腺激素释放激素刺激的催乳素水平有明显变化。本文讨论了催乳素水平升高的正常化可能继发于雌激素降低以及子宫内膜异位症患者对雌激素诱导的催乳素分泌敏感性增加的可能性。
