Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University Shanghai Medical College, Shanghai, China.
Shanghai Institute of Clinical Bioinformatics, Shanghai, China.
Clin Transl Med. 2022 May;12(5):e863. doi: 10.1002/ctm2.863.
Nuclear lipid metabolism and metabolites play important roles in regulation of lipid-lipid, lipid-gene, lipid-chromatin, lipid-membrane and lipid-protein interactions to maintain the nuclear microenvironment, three-dimensional chromatin architecture, gene expression and transcription and biological function. This Editorial highlights the value of lipid-gene interaction in the identification and development of biomarkers and targets and emphasizes the significance of inter-regulation between lipids and genes in innovation and application of precise therapies for patients. Regulatory functions of nuclear lipid dynamics and biophysics modify transcriptomic expression, and modification (lipotranscriptome) can be a new approach for discovery and development of disease-specific diagnoses and therapies, although there are several challenges to be overcome. Better understanding of how lipid-based changes of nuclear functions and transcriptomic profiles modify clinical phenomes will provide new insights to understand molecular mechanisms of diseases and to develop spatiotemporal molecular medicine diagnostics and therapeutics.
核脂质代谢和代谢物在调节脂质-脂质、脂质-基因、脂质-染色质、脂质-膜和脂质-蛋白相互作用方面发挥着重要作用，以维持核微环境、三维染色质结构、基因表达和转录以及生物学功能。本社论强调了脂质-基因相互作用在生物标志物和靶点鉴定和开发中的价值，并强调了脂质和基因之间相互调节在创新和应用精准治疗患者方面的重要性。核脂质动力学和生物物理学的调节功能改变了转录组的表达，修饰（脂转录组）可以成为发现和开发针对特定疾病的诊断和治疗方法的新途径，尽管还存在一些需要克服的挑战。更好地了解核功能和转录组谱的基于脂质的变化如何改变临床表型，将为理解疾病的分子机制以及开发时空分子医学诊断和治疗方法提供新的见解。
