• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Transcriptomic atlas of GNAT family members in pulmonary epithelia under pathological conditions using single-cell and bulk cell sequencing.

作者信息

Liu Xuanqi, Zheng Nannan, Liu Yifei, Zhu Bijun, Hou Jiayun, Qian Mengjia, Zhang Linlin, Li Liyang, Zeng Yiming, Chen Chengshui, Wang Xiangdong

机构信息

Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Institute for Clinical Science, Shanghai Institute of Clinical Bioinformatics, Shanghai Engineering Research for AI Technology for Cardiopulmonary Diseases, Shanghai, China.

Jinshan Hospital Centre for Tumor Diagnosis and Therapy, Fudan University Shanghai Medical College, Shanghai, China.

出版信息

Clin Transl Med. 2022 Jul;12(7):e841. doi: 10.1002/ctm2.841.

DOI:10.1002/ctm2.841
PMID:35858249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9299758/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea9/9299758/0082f2c80385/CTM2-12-e841-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea9/9299758/3b464d819464/CTM2-12-e841-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea9/9299758/b01894a32804/CTM2-12-e841-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea9/9299758/55872df94f11/CTM2-12-e841-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea9/9299758/0082f2c80385/CTM2-12-e841-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea9/9299758/3b464d819464/CTM2-12-e841-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea9/9299758/b01894a32804/CTM2-12-e841-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea9/9299758/55872df94f11/CTM2-12-e841-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea9/9299758/0082f2c80385/CTM2-12-e841-g004.jpg

相似文献

1
Transcriptomic atlas of GNAT family members in pulmonary epithelia under pathological conditions using single-cell and bulk cell sequencing.使用单细胞和大量细胞测序技术绘制病理条件下肺上皮细胞中GNAT家族成员的转录组图谱。
Clin Transl Med. 2022 Jul;12(7):e841. doi: 10.1002/ctm2.841.
2
Classification and phylogeny for the annotation of novel eukaryotic GNAT acetyltransferases.新型真核 GNAT 乙酰转移酶注释的分类和系统发育。
PLoS Comput Biol. 2020 Dec 23;16(12):e1007988. doi: 10.1371/journal.pcbi.1007988. eCollection 2020 Dec.
3
X-ray structure of the AAC(6')-Ii antibiotic resistance enzyme at 1.8 A resolution; examination of oligomeric arrangements in GNAT superfamily members.分辨率为1.8埃的AAC(6')-Ii抗生素抗性酶的X射线结构;GNAT超家族成员中寡聚排列的研究。
Protein Sci. 2003 Mar;12(3):426-37. doi: 10.1110/ps.0233503.
4
Structural characterization of a GNAT family acetyltransferase from Elizabethkingia anophelis bound to acetyl-CoA reveals a new dimeric interface.从嗜人按蚊伊丽莎白菌中结合乙酰辅酶 A 的 GNAT 家族乙酰转移酶的结构特征揭示了一个新的二聚体界面。
Sci Rep. 2021 Jan 14;11(1):1274. doi: 10.1038/s41598-020-79649-5.
5
Crystal structure of the histone acetyltransferase Hpa2: A tetrameric member of the Gcn5-related N-acetyltransferase superfamily.组蛋白乙酰转移酶Hpa2的晶体结构:Gcn5相关N-乙酰转移酶超家族的四聚体成员。
J Mol Biol. 1999 Dec 17;294(5):1311-25. doi: 10.1006/jmbi.1999.3338.
6
GNAT-like strategy for polyketide chain initiation.聚酮链起始的类GNAT策略。
Science. 2007 Nov 9;318(5852):970-4. doi: 10.1126/science.1148790.
7
Bacterial GCN5-Related N-Acetyltransferases: From Resistance to Regulation.细菌中与GCN5相关的N-乙酰转移酶:从耐药性到调控作用
Biochemistry. 2016 Feb 23;55(7):989-1002. doi: 10.1021/acs.biochem.5b01269. Epub 2016 Feb 9.
8
Crystal structure of Helicobacter pylori pseudaminic acid biosynthesis N-acetyltransferase PseH: implications for substrate specificity and catalysis.幽门螺杆菌假氨基糖生物合成N-乙酰转移酶PseH的晶体结构:对底物特异性和催化作用的启示
PLoS One. 2015 Mar 17;10(3):e0115634. doi: 10.1371/journal.pone.0115634. eCollection 2015.
9
Structural characterization of a Gcn5-related N-acetyltransferase from Staphylococcus aureus.来自金黄色葡萄球菌的一种与Gcn5相关的N-乙酰转移酶的结构表征
PLoS One. 2014 Aug 13;9(8):e102348. doi: 10.1371/journal.pone.0102348. eCollection 2014.
10
Structural characterization of ribT from Bacillus subtilis reveals it as a GCN5-related N-acetyltransferase.枯草芽孢杆菌 ribT 的结构表征揭示其为一种 GCN5 相关的 N-乙酰转移酶。
J Struct Biol. 2018 Apr;202(1):70-81. doi: 10.1016/j.jsb.2017.12.006. Epub 2017 Dec 11.

引用本文的文献

1
Lipids and genes: Regulatory roles of lipids in RNA expression.脂质与基因:脂质在 RNA 表达中的调控作用。
Clin Transl Med. 2022 May;12(5):e863. doi: 10.1002/ctm2.863.

本文引用的文献

1
Protective function of interleukin-22 in pulmonary fibrosis.白细胞介素-22 在肺纤维化中的保护作用。
Clin Transl Med. 2021 Aug;11(8):e509. doi: 10.1002/ctm2.509.
2
Regulatory roles of osteopontin in human lung cancer cell epithelial-to-mesenchymal transitions and responses.骨桥蛋白在人肺癌细胞上皮-间质转化和反应中的调控作用。
Clin Transl Med. 2021 Jul;11(7):e486. doi: 10.1002/ctm2.486.
3
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis.单细胞 RNA 测序揭示特发性肺纤维化中异位和异常的肺驻留细胞群体。
Sci Adv. 2020 Jul 8;6(28):eaba1983. doi: 10.1126/sciadv.aba1983. eCollection 2020 Jul.
4
Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma.单细胞 RNA 测序显示转移性肺腺癌的分子和细胞重编程。
Nat Commun. 2020 May 8;11(1):2285. doi: 10.1038/s41467-020-16164-1.
5
B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids.膳食纤维衍生的短链脂肪酸通过 B 细胞内在的表观遗传调控抗体反应。
Nat Commun. 2020 Jan 2;11(1):60. doi: 10.1038/s41467-019-13603-6.
6
Cigarette smoke affects the onco-suppressor DAB2IP expression in bronchial epithelial cells of COPD patients.香烟烟雾影响 COPD 患者支气管上皮细胞中的抑癌基因 DAB2IP 的表达。
Sci Rep. 2019 Oct 30;9(1):15682. doi: 10.1038/s41598-019-52179-5.
7
Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease.单细胞分析揭示了系统性硬皮病相关间质性肺病中成纤维细胞的异质性和肌成纤维细胞。
Ann Rheum Dis. 2019 Oct;78(10):1379-1387. doi: 10.1136/annrheumdis-2018-214865. Epub 2019 Aug 12.
8
N-Acetyltransferase 10 Enhances Doxorubicin Resistance in Human Hepatocellular Carcinoma Cell Lines by Promoting the Epithelial-to-Mesenchymal Transition.N-乙酰基转移酶 10 通过促进上皮-间充质转化增强人肝癌细胞系对多柔比星的耐药性。
Oxid Med Cell Longev. 2019 Jul 1;2019:7561879. doi: 10.1155/2019/7561879. eCollection 2019.
9
Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis.特发性肺纤维化中增殖的 SPP1/MERTK 表达巨噬细胞。
Eur Respir J. 2019 Aug 22;54(2). doi: 10.1183/13993003.02441-2018. Print 2019 Aug.
10
Phenotype molding of stromal cells in the lung tumor microenvironment.肺肿瘤微环境中基质细胞的表型塑造。
Nat Med. 2018 Aug;24(8):1277-1289. doi: 10.1038/s41591-018-0096-5. Epub 2018 Jul 9.