邻炔基芳基异吲哚的去芳构化碘环化反应。

Dearomative Iodocyclization of -(-Alkynyl)aryl Isoindole.

机构信息

School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China.

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062, China.

出版信息

J Org Chem. 2022 Jun 3;87(11):7531-7535. doi: 10.1021/acs.joc.2c00424. Epub 2022 May 19.

DOI:10.1021/acs.joc.2c00424

PMID:35588537

Abstract

We present a dearomative iodocyclization of (-alkynyl)aryl isoindole here, which affords various biologically active benzoindoleazine skeletons containing alkenyl iodine. The products can further undergo cycloaddition or coupling reactions to afford a series of highly functionalized N-fused polycyclic scaffolds.

摘要

我们在此展示了一种（-炔基）芳基异吲哚的去芳构化碘环化反应，该反应可以得到各种含有烯基碘的生物活性苯并吲哚嗪骨架。这些产物可以进一步进行环加成或偶联反应，得到一系列高度官能化的 N-稠合多环支架。