State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; School of Chemical & Environmental Engineering, China University of Mining and Technology-Beijing, Beijing 100083, China.
Environ Int. 2022 Jul;165:107289. doi: 10.1016/j.envint.2022.107289. Epub 2022 May 11.
Environmental risks caused by emerging per- and polyfluoroalkyl substances (PFASs) have attracted increasing attention. As an important substitute for perfluorooctane sulfonate (PFOS), sodium p-perfluorous nonenoxybenzene sulfonate (OBS) is widely used as a firefighting foam additive and oil recovery agent in China. This study reported the tissue distribution of OBS in KM mice that were administered a dose of OBS at 10 µg/day via daily oral gavage for 7, 14, or 28 days. During exposure, gender-based differences were observed in body weight changes and tissue distribution of OBS. Liver exhibited the highest concentrations (males: 12.57 ± 1.80 µg/g; females: 11.80 ± 5.32 µg/g) and tissue/blood ratios and contributed more than 50% to the whole-body burden of OBS in both male and female mice, showing its ability to enrich PFASs. Furthermore, there were certain differences in the distribution characteristics of the three OBS isomers. Based on its bioaccumulation potential and widespread use, further studies are required on the human exposure risks of OBS.
新兴的全氟和多氟烷基物质 (PFASs) 所造成的环境风险引起了越来越多的关注。作为全氟辛烷磺酸 (PFOS) 的重要替代品，过氧全氟壬基苯磺酸钠 (OBS) 在中国被广泛用作消防泡沫添加剂和采油剂。本研究报告了 OBS 在 KM 小鼠中的组织分布情况，这些小鼠每天通过口服灌胃接受 10µg/day 的 OBS 剂量，连续 7、14 或 28 天。在暴露期间，观察到性别对 OBS 体重变化和组织分布的影响存在差异。肝脏表现出最高的浓度（雄性：12.57±1.80µg/g；雌性：11.80±5.32µg/g）和组织/血液比值，并且在雄性和雌性小鼠中均超过了 OBS 全身负荷的 50%，表明其具有富集 PFASs 的能力。此外，三种 OBS 异构体的分布特征存在一定差异。鉴于其生物蓄积潜力和广泛的用途，需要进一步研究 OBS 对人类暴露的风险。
