Kojima Reiji, Shinohara Ryoji, Kushima Megumi, Horiuchi Sayaka, Otawa Sanae, Yokomichi Hiroshi, Akiyama Yuka, Ooka Tadao, Miyake Kunio, Yamagata Zentaro
Department of Health Sciences, School of Medicine, University of Yamanashi, Yamanashi, Japan.
Center for Birth Cohort Studies, University of Yamanashi, Yamanashi, Japan.
Int Arch Allergy Immunol. 2022;183(10):1062-1070. doi: 10.1159/000524854. Epub 2022 May 19.
It is inconclusive whether prenatal negative life events are a risk for the development of allergic diseases in children or whether social capital modifies the association. The objective of this study was to examine whether women's experiences of such events during pregnancy were associated with the development of allergic diseases in their offspring at 3 years old and whether social capital moderated this association.
We used data from 81,337 mother-child pairs who participated in the Japan Environment and Children's Study. This is a prospective birth cohort recruited between January 2011 and March 2014. We examined the associations between prenatal maternal negative life events (e.g., bereavement, financial, and marital problems) during pregnancy and allergic diseases (asthma, eczema, and food allergies) in children after adjustment for covariates using multivariate logistic regression. We also examined interactions between these life events and social capital, measured as two items, social cohesion and social support.
Prenatal negative life events were significantly associated with doctor-diagnosed asthma at 3 years old with a dose-response relationship (one life event vs. none: adjusted odds ratio 1.13, 95% confidence interval [CI]: 1.07-1.20; two life events vs. none: adjusted odds ratio 1.24, 95% CI: 1.13-1.36; three or more life events vs. none: adjusted odds ratio 1.26, 95% CI: 1.10-1.46; p for trend <0.01). Similar results were observed for eczema and food allergies. There were no interactions between life events and social capital.
Prenatal negative life events may be a risk factor for allergies in children. There was no modification of the effect of these events by social capital.
产前负面生活事件是否是儿童过敏性疾病发展的危险因素，或者社会资本是否会改变这种关联，尚无定论。本研究的目的是检验孕期女性经历此类事件是否与她们3岁后代过敏性疾病的发展有关，以及社会资本是否会调节这种关联。
我们使用了来自81337对母婴的数据，这些母婴参与了日本环境与儿童研究。这是一个在2011年1月至2014年3月期间招募的前瞻性出生队列。我们在使用多变量逻辑回归对协变量进行调整后，研究了孕期产前母亲负面生活事件（如丧亲、经济和婚姻问题）与儿童过敏性疾病（哮喘、湿疹和食物过敏）之间的关联。我们还研究了这些生活事件与以社会凝聚力和社会支持这两个项目衡量的社会资本之间的相互作用。
产前负面生活事件与3岁时医生诊断的哮喘显著相关，存在剂量反应关系（一个生活事件与无生活事件相比：调整后的优势比为1.13，95%置信区间[CI]：1.07-1.20；两个生活事件与无生活事件相比：调整后的优势比为1.24，95%CI：1.13-1.36；三个或更多生活事件与无生活事件相比：调整后的优势比为1.26，95%CI：1.10-1.46；趋势p<0.01）。湿疹和食物过敏也观察到类似结果。生活事件与社会资本之间没有相互作用。
产前负面生活事件可能是儿童过敏的一个危险因素。社会资本并未改变这些事件的影响。
