Department of Obstetrics and Fetal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Australia.
J Allergy Clin Immunol. 2014 Jul;134(1):160-9. doi: 10.1016/j.jaci.2014.01.033. Epub 2014 Mar 21.
There is evidence to suggest an association between prenatal maternal stress and the development of asthma or other atopic diseases in offspring. Yet, insights on the lasting effect of multiple, common prenatal stressors are rare, and the effects of prenatal timing are poorly understood. Further, it remains elusive if prenatal life events modify the risk for atopic diseases in the context of a parental predisposition to atopy.
We tested whether women's experiences of common, adverse life events during the first or second half of pregnancy predicted the risk of developing atopic diseases in their children and whether a reported parental atopic disease moderated this association.
We calculated the odds of a child developing asthma, eczema, and/or allergic rhinitis at ages 6 or 14 years, depending on maternal prenatal exposure to negative life events in a sample of 1587 children from the Western Australian Pregnancy Cohort (Raine) Study by using multivariable logistic regression.
We observed that the likelihood of asthma and eczema at age 14 years was significantly increased in children of mothers who had experienced adverse life events during the second half of gestation (1 life event: adjusted odds ratio for asthma, 2.08 [95% CI, 1.22-3.54]). A stronger increase in the odds to develop asthma upon prenatal life events was present in children of mothers without asthma compared with mothers with asthma.
Maternal adverse life events during the second half of gestation are linked to an increased risk for the development of atopic disorders, asthma, and eczema, in the case of asthma, particularly in the absence of a maternal asthma.
有证据表明，孕妇在产前的压力与后代患哮喘或其他特应性疾病之间存在关联。然而，对于多种常见产前应激源的持久影响的深入了解很少，而且产前时间的影响也知之甚少。此外，在父母有特应性倾向的情况下，产前生活事件是否会改变特应性疾病的风险，目前仍不清楚。
我们测试了女性在妊娠前半期或后半期经历的常见不良生活事件是否会预测其子女患特应性疾病的风险，以及报告的父母特应性疾病是否会调节这种关联。
我们通过多变量逻辑回归，根据来自西澳大利亚妊娠队列研究（Raine）的 1587 名儿童样本中母亲在产前暴露于负面生活事件的情况，计算了儿童在 6 岁或 14 岁时患哮喘、湿疹和/或过敏性鼻炎的几率。
我们发现，在妊娠后半期经历过不良生活事件的母亲所生的孩子，在 14 岁时患哮喘和湿疹的可能性显著增加（1 次生活事件：哮喘的调整后比值比为 2.08[95%置信区间，1.22-3.54]）。与有哮喘的母亲相比，没有哮喘的母亲的孩子在经历产前生活事件后，患哮喘的几率增加得更强。
妊娠后半期母亲的不良生活事件与特应性疾病、哮喘和湿疹的发病风险增加有关，在哮喘的情况下，特别是在母亲没有哮喘的情况下。
