基质蛋白堵住漏洞：周细胞如何抑制血脑屏障转胞吞作用。
Matrix proteins plug a hole: How pericytes suppress blood brain barrier transcytosis.
机构信息
Department of Anatomy and Cell Biology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA.
Department of Anatomy and Cell Biology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA.
出版信息
Neuron. 2022 May 18;110(10):1601-1603. doi: 10.1016/j.neuron.2022.04.011.
Abstract
How is the brain so efficient at excluding proteins, drugs, and immune cells from the blood? In this issue of Neuron, Ayloo et al. (2022) find that an extracellular matrix protein secreted by CNS pericytes shuts down endocytic transport in blood brain barrier endothelial cells.
摘要
大脑是如何高效地将蛋白质、药物和免疫细胞从血液中排除出去的？在本期《神经元》杂志上，Ayloo 等人（2022）发现，一种由中枢神经系统周细胞分泌的细胞外基质蛋白会使血脑屏障内皮细胞中的内吞运输失活。
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