Faculty of Chemical Sciences, Autonomous University of San Luis Potosí, Mexico.
Research Center for Health Sciences and Biomedicine, Autonomous University of San Luis Potosí, Mexico.
Biochim Biophys Acta Mol Cell Res. 2022 Sep;1869(9):119297. doi: 10.1016/j.bbamcr.2022.119297. Epub 2022 May 16.
Since their discovery, arylamine N-acetyltransferases 1 and 2 (NAT1 and NAT2, respectively) have been associated with the metabolism of xenobiotics. NAT2 is the main factor in the therapeutic success of tuberculosis treatment due to its role in the biotransformation of isoniazid. However, researchers have started to investigate the possible participation of NAT1 and NAT2 (NATs) in carcinogenesis, although the mechanisms have not been elucidated fully. NATs enzymatic activity is essential in some types of cancer, such as breast cancer and acute lymphoblastic leukemia. Whether NAT1 and/or NAT2 participate in insulin resistance level in diabetes mellitus or in the immune system remains to be explored. Therefore, it is clear that its role in cell physiology has more implications than just metabolizing compounds.
自发现以来，芳香胺 N-乙酰基转移酶 1 和 2（分别为 NAT1 和 NAT2）就与外源性物质的代谢有关。由于其在异烟肼生物转化中的作用，NAT2 是结核病治疗成功的主要因素。然而，研究人员已经开始研究 NAT1 和 NAT2（NATs）在致癌作用中的可能参与，尽管其机制尚未完全阐明。NATs 的酶活性在某些类型的癌症中是必不可少的，如乳腺癌和急性淋巴细胞白血病。NAT1 和/或 NAT2 是否参与糖尿病中的胰岛素抵抗水平或免疫系统仍有待探索。因此，很明显，其在细胞生理学中的作用不仅仅是代谢化合物。
