Department of Anesthesiology in Obstetrics and Gynecology, Gynecology and Obstetrics Clinical Hospital, Poznań University of Medical Sciences, 60-535 Poznan, Poland.
Department of Anesthesiology and Intensive Care, Medical University of Lublin, Jaczewskiego Street 8, 20-954 Lublin, Poland.
Int J Mol Sci. 2022 Jun 25;23(13):7094. doi: 10.3390/ijms23137094.
Brain injury, especially traumatic brain injury (TBI), may induce severe dysfunction of extracerebral organs. Cardiac dysfunction associated with TBI is common and well known as the brain-heart crosstalk, which broadly refers to different cardiac disorders such as cardiac arrhythmias, ischemia, hemodynamic insufficiency, and sudden cardiac death, which corresponds to acute disorders of brain function. TBI-related cardiac dysfunction can both worsen the brain damage and increase the risk of death. TBI-related cardiac disorders have been mainly treated symptomatically. However, the analysis of pathomechanisms of TBI-related cardiac dysfunction has highlighted an important role of melatonin in the prevention and treatment of such disorders. Melatonin is a neurohormone released by the pineal gland. It plays a crucial role in the coordination of the circadian rhythm. Additionally, melatonin possesses strong anti-inflammatory, antioxidative, and antiapoptotic properties and can modulate sympathetic and parasympathetic activities. Melatonin has a protective effect not only on the brain, by attenuating its injury, but on extracranial organs, including the heart. The aim of this study was to analyze the molecular activity of melatonin in terms of TBI-related cardiac disorders. Our article describes the benefits resulting from using melatonin as an adjuvant in protection and treatment of brain injury-induced cardiac dysfunction.
脑损伤，特别是外伤性脑损伤（TBI），可能导致脑外器官严重功能障碍。与 TBI 相关的心脏功能障碍很常见，被称为脑心交流，广义上是指不同的心脏疾病，如心律失常、缺血、血流动力学不足和心源性猝死，与急性脑功能障碍相对应。TBI 相关的心脏功能障碍既会加重脑损伤，又会增加死亡风险。TBI 相关的心脏疾病主要是对症治疗。然而，对 TBI 相关心脏功能障碍的病理机制的分析强调了褪黑素在预防和治疗此类疾病中的重要作用。褪黑素是松果腺分泌的神经激素。它在协调昼夜节律中起着至关重要的作用。此外，褪黑素具有很强的抗炎、抗氧化和抗凋亡作用，并能调节交感和副交感活动。褪黑素不仅对大脑有保护作用，可减轻其损伤，对包括心脏在内的颅外器官也有保护作用。本研究旨在分析褪黑素在 TBI 相关心脏疾病中的分子活性。我们的文章描述了使用褪黑素作为脑损伤诱导的心脏功能障碍的保护和治疗辅助剂的益处。
