仓鼠实验性瘙痒病中的星形胶质细胞反应。

Astrocytic reaction in experimental scrapie in hamsters.

作者信息

Liberski P P

出版信息

J Comp Pathol. 1987 Jan;97(1):73-8. doi: 10.1016/0021-9975(87)90129-0.

Abstract

Severe glial reaction (gliocytosis) in hamsters infected with the 263K strain of scrapie is described. Gliocytosis is an extremely rare phenomenon in scrapie-affected mice. In hamsters, however, it forms an important and stable feature of the neuropathology. Both astrocytic hyperplasia and hypertrophy are described. The author discusses briefly the possible contribution of the scrapie agent and of the host use in the experiments described here to the development of glial changes.

摘要

本文描述了感染263K株羊瘙痒病的仓鼠中严重的胶质细胞反应（胶质细胞增生）。胶质细胞增生在感染羊瘙痒病的小鼠中是极其罕见的现象。然而，在仓鼠中，它是神经病理学的一个重要且稳定的特征。文中描述了星形胶质细胞的增生和肥大。作者简要讨论了羊瘙痒病病原体以及此处实验中宿主因素对胶质细胞变化发展的可能作用。