Huang Y, Li Y H, Xie S L, Rong Z H, Li B S, Kang M, Deng A P, Li Y
Institute for Communicable Disease Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
Institute for AIDS Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2022 May 10;43(5):655-662. doi: 10.3760/cma.j.cn112338-20220121-00061.
2019-nCoV Omicron (B.1.1.529) variant, which has brought new challenges to the prevention and control of COVID-19 pandemic, has the characteristics of stronger transmissibility and more rapid transmission and more significant immune evasion. It took only two months to become a predominant strain worldwide after its identification in South Africa in November 2021. Local epidemics caused by Omicron variant have been reported in several provinces in China. However, the epidemiological characteristics of highly mutated Omicron variant remain unclear. This article summarizes the progress in the research of functional mutations, transmissibility, virulence, immune evasion and cross-reactive immune responses of Omicron variant, to provide references for the effective prevention and control of COVID-19 pandemic caused by Omicron variant.
2019新型冠状病毒奥密克戎（B.1.1.529）变异株给新冠疫情防控带来了新挑战，具有传播力更强、传播速度更快、免疫逃逸更显著的特点。2021年11月在南非被发现后，仅用两个月时间就成为全球主要毒株。我国多个省份已报告由奥密克戎变异株引起的本土疫情。然而，高度变异的奥密克戎变异株的流行病学特征仍不明确。本文总结了奥密克戎变异株功能突变、传播力、毒力、免疫逃逸及交叉反应性免疫应答等方面的研究进展，为有效防控奥密克戎变异株引起的新冠疫情提供参考。
