Division of Software, Yonsei University, Wonju, Republic of Korea.
Department of Mathematics, Yonsei University, Wonju, Republic of Korea.
Sci Rep. 2022 May 19;12(1):8494. doi: 10.1038/s41598-022-12289-z.
Application of minimally invasive methods to enable the measurement of tissue permittivity in the neuromuscular clinic remain elusive. This paper provides a theoretical and modeling study on the measurement of the permittivity of two-dimensional anisotropic tissues such as skeletal muscle with a multi-electrode cross-shaped needle. For this, we design a novel cross-shaped needle with multiple-electrodes and analyse apparent impedance corresponding to the measured impedance. In addition, we propose three methods of estimate anisotropic muscle permittivity. Compared to existing electrical impedance-based needle methods that we have developed, the new needle design and numerical methods associated enable estimating in vivo muscle permittivity values with only a single needle insertion. Being able to measure muscle permittivity directly with a single needle insertion could open up an entirely new area of research with direct clinical application, including using these values to assist in neuromuscular diagnosis and to assess subtle effects of therapeutic intervention on muscle health.
微创方法在神经肌肉临床应用中仍然难以实现对组织介电常数的测量。本文对多电极十字形针测量二维各向异性组织（如骨骼肌）介电常数进行了理论和建模研究。为此，我们设计了一种带有多个电极的新型十字形针，并分析了与测量阻抗相对应的表观阻抗。此外，我们提出了三种估计各向异性肌肉介电常数的方法。与我们已经开发的基于电阻抗的现有针式方法相比，新的针式设计和相关的数值方法可以仅通过单次针插入来估计体内肌肉介电常数值。能够通过单次针插入直接测量肌肉介电常数，可能会开辟一个具有直接临床应用的全新研究领域，包括使用这些值来协助神经肌肉诊断和评估治疗干预对肌肉健康的细微影响。
