Asanoi H, Sasayama S, Iuchi K, Kameyama T
J Am Coll Cardiol. 1987 Apr;9(4):865-71. doi: 10.1016/s0735-1097(87)80243-7.
The acute effects of OPC-8212, a newly synthesized orally effective inotropic agent, were assessed clinically. Eleven patients with moderate congestive heart failure received a single mean dose of 6.5 mg/kg body weight of the drug. Eight hours after administration, the cardiac and stroke work indexes increased by 11% (p less than 0.01) and 20% (p less than 0.005), respectively, with concomitant decreases in the diastolic pulmonary artery (25%, p less than 0.005) and right atrial pressures (33%, p less than 0.01). There were no significant changes in blood pressure or heart rate. The contractile state of the left ventricle was also assessed by the shift of the Starling curve. To construct the function curve, lower body negative pressure was used to regulate the venous return to the heart. An inotropic effect of the agent was confirmed by the shift of this function curve upward and to the left, even when an augmentation of the cardiac output was masked by the marked reduction in preload. The hemodynamic and clinical effects of OPC-8212 were encouraging and the drug appears to be promising for the treatment of congestive heart failure.
对一种新合成的口服有效强心剂OPC - 8212的急性效应进行了临床评估。11例中度充血性心力衰竭患者接受了平均剂量为6.5毫克/千克体重的单次给药。给药8小时后，心脏作功指数和每搏作功指数分别增加了11%（p<0.01）和20%（p<0.005），同时舒张压肺动脉压（25%，p<0.005）和右心房压力降低（33%，p<0.01）。血压和心率无显著变化。还通过斯塔林曲线的移位评估了左心室的收缩状态。为构建功能曲线，采用下体负压来调节心脏的静脉回流。即使心输出量的增加被前负荷的显著降低所掩盖，该功能曲线向上和向左的移位也证实了该药物的强心作用。OPC - 8212的血流动力学和临床效果令人鼓舞，该药物在治疗充血性心力衰竭方面似乎很有前景。
