Weinmann G G, Zacur H, Fish J E
J Allergy Clin Immunol. 1987 Apr;79(4):634-8. doi: 10.1016/s0091-6749(87)80160-4.
The effect of sex hormones on airway function has not been well studied in spite of much evidence to suggest that they are important. We asked if the normal physiologic variation in hormone levels during the menstrual cycle resulted in changes in airway responsiveness and pulmonary function that were not clinically apparent. Nine women with asthma and with normal menstrual cycles but not taking systemic asthma medication were asked to chart temperatures, asthma attacks, and use of asthma medication for four menstrual cycles. We measured baseline spirograms, skin and airway responsiveness to histamine, and serum levels for estradiol, progesterone, and testosterone on approximately day 7 and day 24 of two consecutive cycles. None of the women reported cyclic asthma symptoms, and review of subjects' charts demonstrated no menstrual variation in asthma attacks or use of asthma medications. We found no differences in forced vital capacity or FEV1 early compared to late in the menstrual cycle. Neither did we find a change in airway responsiveness, as indicated by the histamine dose causing a 15% fall in FEV1 or a 35% fall in specific airway conductance. Skin responsiveness as indicated by the wheal response to intradermal histamine was also unchanged. We conclude that physiologic changes in hormone levels during the menstrual cycle are not in themselves associated with changes in airway or skin responsiveness to histamine.
尽管有大量证据表明性激素对气道功能很重要，但对其的研究仍不够充分。我们探讨了月经周期中激素水平的正常生理变化是否会导致气道反应性和肺功能发生临床上不明显的变化。九名患有哮喘且月经周期正常但未服用全身性哮喘药物的女性被要求记录四个月经周期的体温、哮喘发作情况以及哮喘药物的使用情况。我们在连续两个周期的大约第7天和第24天测量了基线肺量计、皮肤和气道对组胺的反应性，以及雌二醇、孕酮和睾酮的血清水平。没有女性报告有周期性哮喘症状，查看受试者的记录也未发现哮喘发作或哮喘药物使用有月经周期变化。我们发现月经周期早期与晚期相比，用力肺活量或第一秒用力呼气量没有差异。我们也未发现气道反应性有变化，这可由使第一秒用力呼气量下降15%或特定气道传导率下降35%的组胺剂量来表明。皮内注射组胺引起的风团反应所显示的皮肤反应性也没有变化。我们得出结论，月经周期中激素水平的生理变化本身与气道或皮肤对组胺的反应性变化无关。
