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坎地沙坦通过影响 Nrf2、NF-κB、Bax/Bcl-2/Cyt-C 和 Ang II/Ang 1-7 信号来预防镉诱导的肝肾综合征。

Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-κB, Bax/Bcl-2/Cyt-C, and Ang II/Ang 1-7 Signals.

机构信息

Department of Medical Histology and Cell Biology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.

Department of Human Anatomy & Embryology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.

出版信息

Biol Trace Elem Res. 2023 Apr;201(4):1846-1863. doi: 10.1007/s12011-022-03286-4. Epub 2022 May 19.

DOI:10.1007/s12011-022-03286-4
PMID:35590119
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9931870/
Abstract

Cadmium (Cd) is a serious pollutant in the environment. Candesartan is an angiotensin II (Ang II) receptor antagonist with promising diverse health benefits. The current study is planned to investigate the hepatorenal protective effects of candesartan against Cd-induced hepatic and renal intoxication. Our results demonstrated that candesartan effectively attenuated Cd-induced hepatorenal intoxication, as evidenced by improving hepatic and renal function biomarkers. Besides, candesartan reversed hepatic and renal histopathological abrasions induced by Cd toxicity. Candesartan antioxidant effect was mediated by Nrf2 activation. Also, candesartan suppressed hepatorenal inflammation by modulating NF-κB/IκB. Moreover, candesartan attenuated Cd hepatorenal apoptosis by upregulating Bcl-2 and downregulating Bax and Cyt-C proteins. Interestingly, these effects are suggested to be an outcome of modulating of Ang II/Ang 1-7 signal. Overall, our findings revealed that candesartan could attenuate Cd-induced hepatorenal intoxication through modulation of Nrf2, NF-κB/IκB, Bax/Bcl-2/Cyt-c, and Ang II/Ang 1-7 signaling pathways.

摘要

镉 (Cd) 是环境中严重的污染物。坎地沙坦是一种血管紧张素 II (Ang II) 受体拮抗剂，具有广泛的潜在健康益处。本研究旨在探讨坎地沙坦对镉诱导的肝肾功能中毒的肝肾功能保护作用。我们的研究结果表明，坎地沙坦能有效减轻镉诱导的肝肾功能中毒，改善肝功能和肾功能生物标志物。此外，坎地沙坦逆转了镉毒性引起的肝肾功能组织病理学损伤。坎地沙坦的抗氧化作用是通过 Nrf2 激活介导的。坎地沙坦还通过调节 NF-κB/IκB 来抑制肝肾功能炎症。此外，坎地沙坦通过上调 Bcl-2 和下调 Bax 和 Cyt-C 蛋白来减轻 Cd 诱导的肝肾功能细胞凋亡。有趣的是，这些作用可能是通过调节 Ang II/Ang 1-7 信号而产生的。总的来说，我们的研究结果表明，坎地沙坦通过调节 Nrf2、NF-κB/IκB、Bax/Bcl-2/Cyt-c 和 Ang II/Ang 1-7 信号通路，可减轻镉诱导的肝肾功能中毒。

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Phytomedicine. 2021 Nov;92:153716. doi: 10.1016/j.phymed.2021.153716. Epub 2021 Aug 25.
2
Modulatory effects of carvacrol against cadmium-induced hepatotoxicity and nephrotoxicity by molecular targeting regulation.香芹酚通过分子靶向调节对镉诱导的肝毒性和肾毒性的调节作用。
Life Sci. 2021 Jul 15;277:119610. doi: 10.1016/j.lfs.2021.119610. Epub 2021 May 11.
3
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Mol Biol Rep. 2023 Jul;50(7):5991-6003. doi: 10.1007/s11033-023-08544-9. Epub 2023 Jun 3.
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Immunopharmacol Immunotoxicol. 2020 Oct;42(5):493-503. doi: 10.1080/08923973.2020.1811307. Epub 2020 Aug 29.
6
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Drug Res (Stuttg). 2020 Nov;70(11):503-511. doi: 10.1055/a-1221-4733. Epub 2020 Aug 20.
7
Involvement of redox status and the nuclear-related factor 2 in protecting against cadmium-induced renal injury with Sana Makki (Cassia senna L.) pre-treatment in male rats.氧化还原状态和核相关因子2参与雄性大鼠经塞纳马克基（番泻叶）预处理预防镉诱导的肾损伤。
An Acad Bras Cienc. 2020;92(2):e20191237. doi: 10.1590/0001-3765202020191237. Epub 2020 Jul 6.
8
Cadmium-induced oxidative stress promotes apoptosis and necrosis through the regulation of the miR-216a-PI3K/AKT axis in common carp lymphocytes and antagonized by selenium.镉诱导的氧化应激通过调节鲫鱼淋巴细胞中的 miR-216a-PI3K/AKT 轴促进细胞凋亡和坏死，并被硒拮抗。
Chemosphere. 2020 Nov;258:127341. doi: 10.1016/j.chemosphere.2020.127341. Epub 2020 Jun 11.
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The Effects of Cadmium Toxicity.镉毒性的影响。
Int J Environ Res Public Health. 2020 May 26;17(11):3782. doi: 10.3390/ijerph17113782.
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[Role of mitochondrial damage in cadmium-induced cell apoptosis and DNA damage of hepatocytes].线粒体损伤在镉诱导的肝细胞凋亡及DNA损伤中的作用
Wei Sheng Yan Jiu. 2020 Mar;49(2):290-297. doi: 10.19813/j.cnki.weishengyanjiu.2020.02.021.