无细胞血浆 RNA 特征作为妊娠健康的替代生物标志物。

Cell-free plasma RNA signatures as a surrogate biomarker of pregnancy health.

机构信息

Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, USA.

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, USA.

出版信息

Med. 2022 Feb 11;3(2):90-92. doi: 10.1016/j.medj.2022.01.010.

DOI:10.1016/j.medj.2022.01.010

PMID:35590212

Abstract

Molecular diagnostics based on sequencing of plasma cell-free DNA has transformed obstetric care by accurately diagnosing fetal aneuploidy in early pregnancy. Rasmussen et al. now report plasma cell-free RNA profiling that could transform obstetrics by providing comprehensive molecular monitoring of pregnancy progression for both healthy and complicated pregnancies such as preeclampsia..

摘要

基于血浆游离细胞 DNA 测序的分子诊断通过在孕早期准确诊断胎儿非整倍体，改变了产科的诊疗模式。Rasmussen 等人现在报告了血浆游离 RNA 谱分析，它可以通过对健康妊娠和子痫前期等复杂妊娠进行全面的分子监测，改变产科的诊疗模式。