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Cell-free DNA as a potential biomarker for preeclampsia.游离DNA作为子痫前期的潜在生物标志物。
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Cell-Free Fetal DNA: A Novel Biomarker for Early Prediction of Pre-eclampsia and Other Obstetric Complications.游离胎儿DNA：一种用于子痫前期及其他产科并发症早期预测的新型生物标志物。
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Cell-free plasma RNA signatures as a surrogate biomarker of pregnancy health.无细胞血浆 RNA 特征作为妊娠健康的替代生物标志物。
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Cell-Free Nucleic Acids for Early Prediction of Preeclampsia.用于子痫前期早期预测的游离核酸
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Is there a future for cell-free fetal dna tests in screening for preeclampsia?游离胎儿DNA检测在子痫前期筛查中是否有未来？
Ginekol Pol. 2019;90(1):55-60. doi: 10.5603/GP.2019.0009.

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Novel biomarkers for preeclampsia: Promises and pitfalls.子痫前期的新型生物标志物：前景与困境
Curr Opin Obstet Gynecol. 2025 Aug 1;37(4):294-301. doi: 10.1097/GCO.0000000000001047. Epub 2025 Jun 3.
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Potential epigenetic markers of clinical diagnostics/therapeutic targets in preeclampsia.子痫前期临床诊断/治疗靶点的潜在表观遗传标志物。
Epigenomics. 2024;16(15-16):1057-1060. doi: 10.1080/17501911.2024.2383558. Epub 2024 Aug 8.
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Cell-free DNA as diagnostic and prognostic biomarkers for adult sepsis: a systematic review and meta-analysis.游离 DNA 作为成人脓毒症的诊断和预后生物标志物的系统评价和荟萃分析。
Sci Rep. 2023 Nov 10;13(1):19624. doi: 10.1038/s41598-023-46663-2.
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eoPred: predicting the placental phenotype of early-onset preeclampsia using public DNA methylation data.eoPred：利用公开的DNA甲基化数据预测早发型子痫前期的胎盘表型
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Lower fetal fraction in clinical cell-free DNA screening results is associated with increased risk of hypertensive disorders of pregnancy.临床游离胎儿 DNA 筛查结果中较低的胎儿分数与妊娠高血压疾病风险增加相关。
Prenat Diagn. 2022 Sep;42(10):1253-1261. doi: 10.1002/pd.6221. Epub 2022 Aug 22.
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Association of fetal fraction with hypertensive disorders of pregnancy incidence and disease severity.胎儿比例与妊娠高血压疾病的发病和严重程度的关系。
Am J Obstet Gynecol MFM. 2022 Sep;4(5):100671. doi: 10.1016/j.ajogmf.2022.100671. Epub 2022 May 27.

本文引用的文献

1
Syncytiotrophoblast stress in preeclampsia: the convergence point for multiple pathways.子痫前期中合体滋养层应激：多种途径的汇聚点。
Am J Obstet Gynecol. 2022 Feb;226(2S):S907-S927. doi: 10.1016/j.ajog.2020.09.047. Epub 2021 Feb 2.
2
Cell-Free Foetal DNA as a Useful Marker for Preeclampsia Prediction.游离胎儿 DNA 作为预测子痫前期的有用标志物。
Reprod Sci. 2021 May;28(5):1563-1569. doi: 10.1007/s43032-021-00466-w. Epub 2021 Jan 21.
3
Circulating Total Cell-Free DNA Levels Are Increased in Hypertensive Disorders of Pregnancy and Associated with Prohypertensive Factors and Adverse Clinical Outcomes.循环总游离 DNA 水平在妊娠高血压疾病中升高，并与高血压因素和不良临床结局相关。
Int J Mol Sci. 2021 Jan 8;22(2):564. doi: 10.3390/ijms22020564.
4
Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin Summary, Number 222.妊娠期高血压与子痫前期：ACOG 实践通报摘要，第 222 号。
Obstet Gynecol. 2020 Jun;135(6):1492-1495. doi: 10.1097/AOG.0000000000003892.
5
Circulating Nucleic Acids in Maternal Plasma and Serum in Pregnancy Complications: Are They Really Useful in Clinical Practice? A Systematic Review.母体血浆和血清中循环核酸在妊娠并发症中的应用：它们在临床实践中真的有用吗？系统评价。
Mol Diagn Ther. 2020 Aug;24(4):409-431. doi: 10.1007/s40291-020-00468-5.
6
Maternal serum mitochondrial DNA (mtDNA) levels are elevated in preeclampsia - A matched case-control study.子痫前期孕妇血清线粒体DNA（mtDNA）水平升高——一项配对病例对照研究。
Pregnancy Hypertens. 2018 Oct;14:195-199. doi: 10.1016/j.preghy.2018.10.003. Epub 2018 Oct 12.
7
Mitochondrial DNA Copy Number in Peripheral Blood in the First Trimester of Pregnancy and Different Preeclampsia Clinical Phenotypes Development: A Pilot Study.妊娠早期外周血线粒体 DNA 拷贝数与不同子痫前期临床表型的发生：一项初步研究。
Reprod Sci. 2019 Aug;26(8):1054-1061. doi: 10.1177/1933719118804410. Epub 2018 Oct 8.
8
Maternal total cell-free DNA in preeclampsia and fetal growth restriction: Evidence of differences in maternal response to abnormal implantation.子痫前期和胎儿生长受限孕妇的母体外周血游离胎儿 DNA：母体对异常着床反应不同的证据。
PLoS One. 2018 Jul 12;13(7):e0200360. doi: 10.1371/journal.pone.0200360. eCollection 2018.
9
Circulating fetal and total cell-free DNA, and sHLA-G in black South African women with gestational hypertension and pre-eclampsia.患有妊娠期高血压和先兆子痫的南非黑人女性体内的循环胎儿及总游离DNA和可溶性人类白细胞抗原G
Hypertens Pregnancy. 2017 Nov;36(4):295-301. doi: 10.1080/10641955.2017.1385794. Epub 2017 Nov 8.
10
Mitochondrial DNA content and methylation in fetal cord blood of pregnancies with placental insufficiency.胎盘功能不全妊娠胎儿脐带血中的线粒体DNA含量与甲基化
Placenta. 2017 Jul;55:63-70. doi: 10.1016/j.placenta.2017.05.008. Epub 2017 May 12.

Cell-free DNA as a potential biomarker for preeclampsia.

作者信息

Palei Ana C

机构信息

Department of Surgery, School of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, MS, USA.

出版信息

Expert Rev Mol Diagn. 2021 Dec;21(12):1253-1256. doi: 10.1080/14737159.2021.1997593. Epub 2021 Oct 29.

DOI:10.1080/14737159.2021.1997593
PMID:34696685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8671212/
Abstract
摘要