基于香豆素的光降解水凝胶：设计、合成、凝胶化及降解动力学
Coumarin-Based Photodegradable Hydrogel: Design, Synthesis, Gelation, and Degradation Kinetics.
作者信息
Azagarsamy Malar A, McKinnon Daniel D, Alge Daniel L, Anseth Kristi S
机构信息
Department of Chemical and Biological Engineering, ‡BioFrontiers Institute, and §Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80303, United States.
Department of Chemical and Biological Engineering, BioFrontiers Institute, and §Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80303, United States.
出版信息
ACS Macro Lett. 2014 Jun 17;3(6):515-519. doi: 10.1021/mz500230p. Epub 2014 May 16.
The design, synthesis, and characterization of a new class of coumarin-based photodegradable hydrogels are reported. Hydrogel formation was achieved rapidly and efficiently under aqueous conditions using copper-catalyzed click chemistry, which afforded excellent control over the rate of network formation. Rapid photodegradation, to the point of reverse gelation, was observed using both 365 and 405 nm light, and micrometer-scale features were eroded using two-photon irradiation at wavelengths as long as 860 nm.
报道了一类新型香豆素基光降解水凝胶的设计、合成与表征。在水相条件下，利用铜催化的点击化学快速有效地实现了水凝胶的形成，从而对网络形成速率进行了出色的控制。使用365和405纳米的光均观察到快速光降解，直至发生逆凝胶化，并且在长达860纳米的波长下通过双光子照射侵蚀了微米级特征。
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