Department of Chemical and Biological Engineering and the BioFrontiers Institute, University of Colorado Boulder, Jennie Smoly Caruthers Biotechnology Building, 3415 Colorado Ave, Boulder, CO, 80303, USA.
Howard Hughes Medical Institute, University of Colorado Boulder, Jennie Smoly Caruthers Biotechnology Building, 3415 Colorado Ave, Boulder, CO, 80303, USA.
Adv Mater. 2017 Mar;29(11). doi: 10.1002/adma.201605001. Epub 2017 Jan 23.
Hydrogels crosslinked by allyl-sulfide-containing molecules are presented. By exposure to light in the presence of a photoinitiator and a free monofunctional thiol, photodegradation is achieved. Both the gelation and degradation are cytocompatible and allow for cell encapsulation and subsequent release. The photodegradation kinetics and depths attainable are superior to those of traditional cell-laden photodegradable hydrogels.
介绍了由含丙烯基硫醚分子交联的水凝胶。通过在光引发剂和游离单官能巯基存在下暴露于光,实现光降解。凝胶化和降解都是细胞相容的,并允许细胞包封和随后的释放。光降解动力学和可达到的深度优于传统的细胞负载光降解水凝胶。