van Zoelen Wendy, Buss Hilda G, Ellebracht Nathan C, Lynd Nathaniel A, Fischer Daniel A, Finlay John, Hill Sophie, Callow Maureen E, Callow James A, Kramer Edward J, Zuckermann Ronald N, Segalman Rachel A
Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.
Materials Science and Engineering Laboratory, National Institute for Standards and Technology, Gaithersburg, Maryland 20899, United States.
ACS Macro Lett. 2014 Apr 15;3(4):364-368. doi: 10.1021/mz500090n. Epub 2014 Mar 28.
Amphiphilic polymers, specifically combinations of hydrophilic and hydrophobic residues, have been shown to be effective as antifouling materials against the algae and diatoms. Here we use the inherent sequence specificity of polypeptoids made by solid-phase synthesis to show that the sequence of hydrophilic (methoxy) and hydrophobic (fluorinated) moieties affects both antifouling and fouling release of . The platform used to test these sequences was a polystyrene--poly(ethylene oxide--allyl glycidyl ether) (PS--P(EO--AGE)) scaffold, where the polypeptoids are attached to the scaffold using thiol-ene click chemistry. The fluorinated moiety is very surface active and directs the surface composition of the polymer thin film. The position and number of fluorinated groups in the polypeptoid are shown to affect both the surface composition and antifouling properties of the film. Specifically, the position of the fluorinated units in the peptoid chain changes the surface chemistry and the antifouling behavior, while the number of fluorinated residues affects the fouling-release properties.
两亲性聚合物，特别是亲水和疏水残基的组合，已被证明是有效的抗藻和抗硅藻污垢材料。在这里，我们利用固相合成制备的类肽的固有序列特异性来表明，亲水（甲氧基）和疏水（氟化）部分的序列会影响抗污垢和污垢释放性能。用于测试这些序列的平台是聚苯乙烯-聚（环氧乙烷-烯丙基缩水甘油醚）（PS-P(EO-AGE)）支架，其中类肽通过硫醇-烯点击化学连接到支架上。氟化部分具有很强的表面活性，可引导聚合物薄膜的表面组成。类肽中氟化基团的位置和数量被证明会影响薄膜的表面组成和抗污垢性能。具体而言，类肽链中氟化单元的位置会改变表面化学性质和抗污垢行为，而氟化残基的数量则会影响污垢释放性能。
