Lowe M R, Batchelor D H
Int Clin Psychopharmacol. 1986 Jul;1 Suppl 1:53-62.
Twelve patients (eight men and four women) suffering from manic depressive disorder who were receiving both lithium and antipsychotic medication had their antipsychotic changed to depot haloperidol decanoate, with their lithium medication remaining unchanged. Successful transfer to haloperidol decanoate was achieved with a reduced incidence of extrapyramidal side effects, and 100% compliance in eight patients who all remained free of hypomanic relapse, including four patients with rapid-cycling disorder. By comparison, in the three years before switching to haloperidol decanoate these four patients had required sixteen admissions for hypomanic relapses resulting in thirty-four months in-patient treatment.
12名患有躁郁症且正在同时服用锂盐和抗精神病药物的患者（8名男性和4名女性），将其抗精神病药物换为癸酸氟哌啶醇长效针剂，锂盐药物保持不变。成功换用癸酸氟哌啶醇后，锥体外系副作用的发生率降低，8名患者的依从性达100%，且均未出现轻躁狂复发，其中包括4名快速循环型障碍患者。相比之下，在换用癸酸氟哌啶醇之前的三年里，这4名患者因轻躁狂复发需要住院16次，住院治疗时间长达34个月。
