Goodwin G M, Haddad P M, Ferrier I N, Aronson J K, Barnes Trh, Cipriani A, Coghill D R, Fazel S, Geddes J R, Grunze H, Holmes E A, Howes O, Hudson S, Hunt N, Jones I, Macmillan I C, McAllister-Williams H, Miklowitz D R, Morriss R, Munafò M, Paton C, Saharkian B J, Saunders Kea, Sinclair Jma, Taylor D, Vieta E, Young A H
University Department of Psychiatry, Warneford Hospital, Oxford, UK
Greater Manchester West Mental Health NHS Foundation Trust, Eccles, Manchester, UK.
J Psychopharmacol. 2016 Jun;30(6):495-553. doi: 10.1177/0269881116636545. Epub 2016 Mar 15.
The British Association for Psychopharmacology guidelines specify the scope and targets of treatment for bipolar disorder. The third version is based explicitly on the available evidence and presented, like previous Clinical Practice Guidelines, as recommendations to aid clinical decision making for practitioners: it may also serve as a source of information for patients and carers, and assist audit. The recommendations are presented together with a more detailed review of the corresponding evidence. A consensus meeting, involving experts in bipolar disorder and its treatment, reviewed key areas and considered the strength of evidence and clinical implications. The guidelines were drawn up after extensive feedback from these participants. The best evidence from randomized controlled trials and, where available, observational studies employing quasi-experimental designs was used to evaluate treatment options. The strength of recommendations has been described using the GRADE approach. The guidelines cover the diagnosis of bipolar disorder, clinical management, and strategies for the use of medicines in short-term treatment of episodes, relapse prevention and stopping treatment. The use of medication is integrated with a coherent approach to psychoeducation and behaviour change.
英国精神药理学会指南明确了双相情感障碍的治疗范围和目标。第三版明确基于现有证据,并如先前的临床实践指南一样,作为帮助从业者进行临床决策的建议呈现:它也可作为患者及其护理者的信息来源,并有助于审计。这些建议还附带了对相应证据的更详细综述。一次由双相情感障碍及其治疗领域的专家参与的共识会议,对关键领域进行了审查,并考量了证据强度和临床意义。这些指南是在收到这些参与者的广泛反馈后制定的。来自随机对照试验以及(若有)采用准实验设计的观察性研究的最佳证据,被用于评估治疗方案。推荐强度采用GRADE方法进行了描述。这些指南涵盖双相情感障碍的诊断、临床管理,以及在发作的短期治疗、预防复发和停止治疗中使用药物的策略。药物的使用与心理教育和行为改变的连贯方法相结合。