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The interaction between polygenic risk score and trauma affects the likelihood of post-traumatic stress disorder in female victims of sexual assault.多基因风险评分与创伤之间的相互作用影响性侵女性受害者创伤后应激障碍的可能性。
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From genetics to systems biology of stress-related mental disorders.从应激相关精神障碍的遗传学到系统生物学
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Psychological legacies of intergenerational trauma under South African apartheid: Prenatal stress predicts greater vulnerability to the psychological impacts of future stress exposure during late adolescence and early adulthood in Soweto, South Africa.南非种族隔离制度下代际创伤的心理遗留问题：在南非索韦托，产前应激预示着在青少年后期和成年早期，更容易受到未来应激暴露的心理影响。
J Child Psychol Psychiatry. 2023 Jan;64(1):110-124. doi: 10.1111/jcpp.13672. Epub 2022 Jul 19.
2
Epigenomic mediation after adverse childhood experiences: a systematic review and meta-analysis.童年不良经历后的表观基因组介导作用：一项系统评价和荟萃分析
Forensic Sci Res. 2019 Aug 26;6(2):103-114. doi: 10.1080/20961790.2019.1641954. eCollection 2021.
3
Combined effects of genotype and childhood adversity shape variability of DNA methylation across age.基因型与童年逆境的综合影响塑造了不同年龄段DNA甲基化的变异性。
Transl Psychiatry. 2021 Feb 1;11(1):88. doi: 10.1038/s41398-020-01147-z.
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Transcriptomic organization of the human brain in post-traumatic stress disorder.创伤后应激障碍患者大脑的转录组组织。
Nat Neurosci. 2021 Jan;24(1):24-33. doi: 10.1038/s41593-020-00748-7. Epub 2020 Dec 21.
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Intergenerational trauma is associated with expression alterations in glucocorticoid- and immune-related genes.代际创伤与糖皮质激素和免疫相关基因的表达改变有关。
Neuropsychopharmacology. 2021 Mar;46(4):763-773. doi: 10.1038/s41386-020-00900-8. Epub 2020 Nov 10.
6
Maternal trauma and fear history predict methylation and gene expression in newborns.母亲的创伤和恐惧史可预测新生儿的甲基化和基因表达。
PeerJ. 2020 May 22;8:e8858. doi: 10.7717/peerj.8858. eCollection 2020.
7
Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons.重度抑郁症前额叶皮质的单核转录组学研究表明少突胶质前体细胞和兴奋性神经元与之有关。
Nat Neurosci. 2020 Jun;23(6):771-781. doi: 10.1038/s41593-020-0621-y. Epub 2020 Apr 27.
8
Intergenerational Effects of Maternal Holocaust Exposure on Methylation.母婴大屠杀暴露对甲基化的代际影响。
Am J Psychiatry. 2020 Aug 1;177(8):744-753. doi: 10.1176/appi.ajp.2019.19060618. Epub 2020 Apr 21.
9
Genomic influences on self-reported childhood maltreatment.遗传因素对自我报告的儿童期虐待的影响。
Transl Psychiatry. 2020 Jan 27;10(1):38. doi: 10.1038/s41398-020-0706-0.
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The Conserved Transcriptional Response to Adversity.对逆境的保守转录反应。
Curr Opin Behav Sci. 2019 Aug;28:31-37. doi: 10.1016/j.cobeha.2019.01.008. Epub 2019 Feb 25.

The Biological Effects of Trauma.

作者信息

Dalvie Shareefa, Daskalakis Nikolaos P

机构信息

Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.

Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.

出版信息

Complex Psychiatry. 2021 Aug;7(1-2):16-18. doi: 10.1159/000517236. Epub 2021 May 18.

DOI:10.1159/000517236
PMID:35592091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8443929/
Abstract
摘要