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血糖波动加剧心肌纤维化：核因子-κB介导的核苷酸结合寡聚化结构域样受体蛋白3炎性小体激活

Glucose Fluctuations Aggravate Myocardial Fibrosis the Nuclear Factor-κB-Mediated Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Inflammasome Activation.

作者信息

Zhang Zhen-Ye, Dang Shi-Peng, Li Shan-Shan, Liu Ying, Qi Miao-Miao, Wang Ning, Miao Ling-Feng, Wu Ying, Li Xiao-Yan, Wang Chun-Xin, Qian Ling-Ling, Wang Ru-Xing

机构信息

Department of Cardiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.

Department of Medical Laboratory, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.

出版信息

Front Cardiovasc Med. 2022 May 3;9:748183. doi: 10.3389/fcvm.2022.748183. eCollection 2022.

DOI:10.3389/fcvm.2022.748183
PMID:35592403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9110689/
Abstract

BACKGROUND

Glucose fluctuations may be associated with myocardial fibrosis. This study aimed to investigate the underlying mechanisms of glucose fluctuation-related myocardial fibrosis.

METHODS

Streptozotocin (STZ)-injected type 1 diabetic rats were randomized to five groups: the controlled blood glucose (CBG) group, uncontrolled blood glucose (UBG) group, fluctuated blood glucose (FBG) group, FBG rats injected with 0.9% sodium chloride (NaCl) (FBG + NaCl) group, and FBG rats injected with MCC950 (FBG + MCC950) group. Eight weeks later, left ventricular function was evaluated by echocardiography and myocardial fibrosis was observed by Masson trichrome staining. The primary neonatal rat cardiac fibroblasts were cultured with different concentrations of glucose .

RESULTS

The left ventricular function was impaired and myocardial fibrosis was aggravated most significantly in the FBG group compared with the CBG and UBG groups. The levels of interleukin (IL)-1β, IL-18, transforming growth factor-β1 (TGF-β1), collagen type 1 (collagen I), nuclear factor (NF)-κB, and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome were significantly increased in the FBG group. , the inhibition of NF-κB and inflammasome reversed these effects. , NLRP3 inhibition with MCC950 reversed left ventricular systolic dysfunction and myocardial fibrosis induced by glucose fluctuations.

CONCLUSION

Glucose fluctuations promote diabetic myocardial fibrosis by the NF-κB-mediated inflammasome activation.

摘要

背景

血糖波动可能与心肌纤维化有关。本研究旨在探讨血糖波动相关心肌纤维化的潜在机制。

方法

将注射链脲佐菌素（STZ）的1型糖尿病大鼠随机分为五组：血糖控制组（CBG）、血糖未控制组（UBG）、血糖波动组（FBG）、注射0.9%氯化钠（NaCl）的FBG大鼠组（FBG + NaCl）和注射MCC950的FBG大鼠组（FBG + MCC950）。八周后，通过超声心动图评估左心室功能，并用Masson三色染色法观察心肌纤维化情况。用不同浓度的葡萄糖培养原代新生大鼠心脏成纤维细胞。

结果

与CBG组和UBG组相比，FBG组左心室功能受损最显著，心肌纤维化加重。FBG组白细胞介素（IL）-1β、IL-18、转化生长因子-β1（TGF-β1）、I型胶原（collagen I）、核因子（NF）-κB和核苷酸结合寡聚化结构域样受体蛋白3（NLRP3）炎性小体水平显著升高。NF-κB和炎性小体的抑制可逆转这些作用。用MCC950抑制NLRP3可逆转血糖波动诱导的左心室收缩功能障碍和心肌纤维化。

结论

血糖波动通过NF-κB介导的炎性小体激活促进糖尿病心肌纤维化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/303d/9110689/60bdf62646f4/fcvm-09-748183-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/303d/9110689/2936e759f4de/fcvm-09-748183-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/303d/9110689/afdc2261775c/fcvm-09-748183-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/303d/9110689/a556fbd56f1a/fcvm-09-748183-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/303d/9110689/d0eca54fed11/fcvm-09-748183-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/303d/9110689/24ff6c579327/fcvm-09-748183-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/303d/9110689/91fa88a75b5b/fcvm-09-748183-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/303d/9110689/60bdf62646f4/fcvm-09-748183-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/303d/9110689/2936e759f4de/fcvm-09-748183-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/303d/9110689/afdc2261775c/fcvm-09-748183-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/303d/9110689/a556fbd56f1a/fcvm-09-748183-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/303d/9110689/d0eca54fed11/fcvm-09-748183-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/303d/9110689/24ff6c579327/fcvm-09-748183-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/303d/9110689/91fa88a75b5b/fcvm-09-748183-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/303d/9110689/60bdf62646f4/fcvm-09-748183-g007.jpg

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