Rahman Kurnia H, Surboyo Meircurius D C, Radithia Desiana, Parmadiati Adiastuti E, Wihandono Asdi, Ernawati Diah S
Oral Medicine Recidency, Faculty of Dental Medicine, Universitas Airlangga, Indonesia.
Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Indonesia.
J Taibah Univ Med Sci. 2021 Nov 15;17(2):326-331. doi: 10.1016/j.jtumed.2021.09.011. eCollection 2022 Apr.
Essential thrombocythemia is a condition caused by a high platelet count and a positive JAK2 (V617F) mutation. There is an increasing occurrence of malignancy, such as oral squamous cell carcinoma (OSCC), in patients with essential thrombocythemia. The objective of this case report is to document the novel instance of a patient with OSCC after being diagnosed with essential thrombocythemia and a positive JAK2 (V617F) mutation. The patient was a 42-year-old female who complained of an ulcer and pain in the dextral lateral tongue for three months. After two weeks, the pain diminished; however, there was swelling and tenderness on the ulcer. The patient was diagnosed with essential thrombocythemia and a positive JAK2 (V617F) mutation and began undergoing hydroxyurea therapy three months prior to the OSCC diagnosis. The diagnosis of OSCC was based on exfoliative cytology and MRI. The patient was treated with an antiseptic mouthwash to prevent secondary infection and referred to an oncologist to manage the OSCC. It is possible to use the suspected markers of thrombocytosis and a positive JAK2 (V617F) mutation to define the OSCC diagnosis.
原发性血小板增多症是一种由血小板计数升高和JAK2（V617F）突变阳性引起的病症。原发性血小板增多症患者发生恶性肿瘤的情况日益增多，如口腔鳞状细胞癌（OSCC）。本病例报告的目的是记录一例在被诊断为原发性血小板增多症且JAK2（V617F）突变阳性后发生OSCC的新病例。该患者为一名42岁女性，主诉右侧舌缘溃疡和疼痛三个月。两周后，疼痛减轻；然而，溃疡处出现肿胀和压痛。该患者被诊断为原发性血小板增多症且JAK2（V617F）突变阳性，并在OSCC诊断前三个月开始接受羟基脲治疗。OSCC的诊断基于脱落细胞学检查和磁共振成像。该患者接受了抗菌漱口水治疗以预防继发感染，并转诊至肿瘤学家处治疗OSCC。有可能使用血小板增多症的可疑标志物和JAK2（V617F）突变阳性来明确OSCC的诊断。
