Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Inflammatory Bowel Disease Center, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
J Leukoc Biol. 2022 Aug;112(2):313-331. doi: 10.1002/JLB.3RU0322-176R. Epub 2022 May 20.
The intestinal tract is a complex ecosystem where numerous cell types of epithelial, immune, neuronal, and endothelial origin coexist in an intertwined, highly organized manner. The functional equilibrium of the intestine relies heavily on the proper crosstalk and cooperation among each cell population. Furthermore, macrophages are versatile, innate immune cells that participate widely in the modulation of inflammation and tissue remodeling. Emerging evidence suggest that macrophages are central in orchestrating tissue homeostasis. Herein, we describe how macrophages interact with epithelial cells, neurons, and other types of mesenchymal cells under the context of intestinal inflammation, followed by the therapeutic implications of cellular crosstalk pertaining to the treatment of inflammatory bowel disease.
肠道是一个复杂的生态系统，其中有许多上皮细胞、免疫细胞、神经元和内皮细胞起源的细胞类型以交织的、高度组织化的方式共存。肠道的功能平衡很大程度上依赖于每个细胞群体之间的适当串扰和合作。此外，巨噬细胞是多功能的先天免疫细胞，广泛参与炎症和组织重塑的调节。新出现的证据表明，巨噬细胞在协调组织稳态中起着核心作用。本文描述了巨噬细胞在肠道炎症背景下如何与上皮细胞、神经元和其他类型的间充质细胞相互作用，然后讨论了细胞串扰在治疗炎症性肠病方面的治疗意义。
