Shanghai East Hospital, Nanjing Medical University, Nanjing 211166, Jiangsu Province, China.
Department of Emergency Medicine and Critical Care, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
J Mater Chem B. 2022 Jun 15;10(23):4442-4451. doi: 10.1039/d2tb00587e.
High intensity focused ultrasound (HIFU), as one of the most advanced and preferred cancer treatment modes, has shown great promise due to its minimal invasiveness and irradiation-free nature. However, a key limiting factor for its further clinical application is its relatively low therapeutic potency. In this study, CaO@SiO NPs were developed for efficient O bubble-assisted HIFU surgery against tumors. After entering the tumor sites, these nanoparticles can release O and HO, achieving enhancement of US imaging signals and improved potency of HIFU surgery. In addition, local temperature increase during HIFU treatment could trigger O generation by the conversion of unstable HO into O gas, further augmenting the efficacy of HIFU treatment. This work not only provides a paradigm of CaO for cancer management in nanomedicine, but also presents an efficient way for bubble-enhanced HIFU surgery.
高强度聚焦超声（HIFU）作为一种最先进和首选的癌症治疗模式，由于其微创和无辐射的特性，显示出巨大的应用前景。然而，其进一步临床应用的一个关键限制因素是其相对较低的治疗效力。在这项研究中，开发了 CaO@SiO2 纳米颗粒用于高效的 O 泡辅助 HIFU 肿瘤手术。这些纳米颗粒进入肿瘤部位后，可以释放 O 和 HO，增强 US 成像信号，并提高 HIFU 手术的效力。此外，HIFU 治疗过程中的局部温度升高可以通过不稳定的 HO 转化为 O 气体来触发 O 的产生，进一步增强 HIFU 治疗的效果。这项工作不仅为纳米医学中的癌症管理提供了 CaO 的范例，也为气泡增强 HIFU 手术提供了一种有效的方法。
