Bubble-assisted HIFU ablation enabled by calcium peroxide.

High intensity focused ultrasound (HIFU), as one of the most advanced and preferred cancer treatment modes, has shown great promise due to its minimal invasiveness and irradiation-free nature. However, a key limiting factor for its further clinical application is its relatively low therapeutic potency. In this study, CaO@SiO NPs were developed for efficient O bubble-assisted HIFU surgery against tumors. After entering the tumor sites, these nanoparticles can release O and HO, achieving enhancement of US imaging signals and improved potency of HIFU surgery. In addition, local temperature increase during HIFU treatment could trigger O generation by the conversion of unstable HO into O gas, further augmenting the efficacy of HIFU treatment. This work not only provides a paradigm of CaO for cancer management in nanomedicine, but also presents an efficient way for bubble-enhanced HIFU surgery.