Department of Joint Surgery, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China.
Mol Med Rep. 2022 Jul;26(1). doi: 10.3892/mmr.2022.12743. Epub 2022 May 20.
Bone marrow mesenchymal stem cells (BMSCs) can differentiate into osteoblasts, chondrocytes, adipocytes and even myoblasts, and are therefore defined as pluripotent cells. BMSCs have become extremely important seed cells in gene therapy, tissue engineering, cell replacement therapy and regenerative medicine due to their potential in multilineage differentiation, self‑renewal, immune regulation and other fields. Circular RNAs (circRNAs) are a class of non‑coding RNAs that are widely present in eukaryotic cells. Unlike standard linear RNAs, circRNAs form covalently closed continuous loops with no 5' or 3' polarity. circRNAs are abundantly expressed in cells and tissues, and are highly conserved and relatively stable during evolution. Numerous studies have shown that circRNAs play an important role in the osteogenic differentiation of BMSCs. Further studies on the role of circRNAs in the osteogenic differentiation of BMSCs can provide a new theoretical and experimental basis for bone tissue engineering and clinical treatment.
骨髓间充质干细胞（BMSCs）能够分化为成骨细胞、软骨细胞、脂肪细胞甚至成肌细胞，因此被定义为多能细胞。BMSCs 具有多向分化、自我更新、免疫调节等潜能，在基因治疗、组织工程、细胞替代治疗和再生医学等领域已成为极其重要的种子细胞。环状 RNA（circRNA）是一类广泛存在于真核细胞中的非编码 RNA。与标准线性 RNA 不同，circRNA 形成共价闭合的连续环，没有 5' 或 3' 极性。circRNA 在细胞和组织中大量表达，在进化过程中高度保守且相对稳定。大量研究表明，circRNA 在 BMSCs 的成骨分化中发挥重要作用。进一步研究 circRNA 在 BMSCs 成骨分化中的作用，可以为骨组织工程和临床治疗提供新的理论和实验依据。
