恒河猴实验性麻风病：尸检结果

Experimental leprosy in a rhesus monkey: necropsy findings.

作者信息

Baskin G B, Gormus B J, Martin L N, Wolf R H, Murphey-Corb M, Walsh G P, Binford C H, Meyers W M, Malaty R

出版信息

Int J Lepr Other Mycobact Dis. 1987 Mar;55(1):109-15.

Abstract

A 6-month-old male rhesus monkey (Macaca mulatta) was inoculated intravenously and intracutaneously with Mycobacterium leprae obtained from a naturally infected mangabey monkey. The animal developed generalized lepromatous leprosy, and was killed for pathological examination 56 months after inoculation. Lesions were observed in the skin, nasal mucosa, peripheral nerves, and peripheral lymph nodes, with relative sparing of viscera. The monkey was carefully evaluated for the retrovirus STLV-III infection and was found negative. The rhesus monkey thus provides another animal model for the study of leprosy.

摘要

一只6个月大的雄性恒河猴（猕猴）通过静脉内和皮内接种从一只自然感染的白眉猴身上获取的麻风分枝杆菌。这只动物患上了全身性瘤型麻风，并在接种后56个月被处死进行病理检查。在皮肤、鼻粘膜、外周神经和外周淋巴结中观察到病变，内脏相对未受影响。对这只猴子进行了仔细的逆转录病毒STLV-III感染评估，结果为阴性。因此，恒河猴为麻风病研究提供了另一种动物模型。