Department of Pediatrics, Sørlandet Hospital, Arendal, Norway.
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Brain Behav. 2022 Jun;12(6):e2608. doi: 10.1002/brb3.2608. Epub 2022 May 20.
Long-term cognitive problems after neuroborreliosis treatment remain a subject of debate. We have previously shown that cognitive problems are not present in the acute phase of neuroborreliosis, although fatigue is common. The aim of this study was to re-assess the same patient cohort and evaluate long-term outcomes.
In this follow-up, we re-assessed 58 patients with well-characterized neuroborreliosis 12 months after completing treatment. The same protocol with eight subtests measuring attention and processing speed and the Fatigue Severity Scale (FSS) were used to compare the results from the acute phase to 12 months post treatment.
We found no changes in attention or processing speed but a reduction in the level of fatigue (median score on FSS: 4.9 vs. 3.9, p < .001) from the acute phase to 12 months post treatment.
The patient group did not develop problems with attention or processing speed post treatment, while the level of fatigue decreased.
神经梅毒治疗后长期认知问题仍存在争议。我们之前的研究表明，尽管疲劳很常见，但在神经梅毒的急性期不存在认知问题。本研究的目的是重新评估同一患者队列并评估长期结果。
在本次随访中，我们在完成治疗 12 个月后重新评估了 58 名明确诊断为神经梅毒的患者。使用相同的方案，包括八项注意力和处理速度测试和疲劳严重程度量表（FSS），将急性期和治疗后 12 个月的结果进行比较。
我们没有发现注意力或处理速度的变化，但疲劳程度从急性期到治疗后 12 个月有所下降（FSS 中位数评分：4.9 比 3.9，p<0.001）。
患者组在治疗后没有出现注意力或处理速度问题，而疲劳程度有所下降。
