Department of Oral Medicine, The Faculty of Dental Medicine, Damascus University, Damascus, Syria.
Department of Oral Medicine and Pathology, The Faculty of Dental Medicine, AL-Sham Privat University, Damascus, Syria.
Oral Dis. 2023 Jul;29(5):2256-2264. doi: 10.1111/odi.14261. Epub 2022 May 30.
The use of autologous platelet concentrates has shown growing evidence as a promising therapy. We conducted a split-mouth study to evaluate the effectiveness of injectable platelet-rich fibrin (PRF) compared with triamcinolone acetonide (TA) in the treatment of oral lichen planus (OLP).
This split-mouth randomized trial included 12 patients with symptomatic, bilateral OLP lesions. The participants were randomly allocated to receive a 1-ml intralesional PRF injection on one side of the buccal mucosa and a 0.5-ml TA injection on the counterpart side. The application was performed once a week for 4 weeks. The outcomes were measured using a visual analog scale score, REU score, and lesion areas.
Both injectable TA and PRF were effective in the management of oral lichen planus. After 4 weeks of treatment, there was an average reduction in the VAS score (68.5% i-PRF, 91% TA) and an average reduction in the REU score (74% i-PRF, 91% TA). There were no statistically significant differences between the two treatment methods (p > 0.05).
Intralesional injection with TA showed more effectiveness than i-PRF in the management of OPL lesions. Although, i-PRF cannot be considered a first-line treatment option, it showed promising alternative therapy choice with no side effects.
自体血小板浓缩物的应用已被证明是一种有前途的治疗方法，其疗效不断得到证实。我们进行了一项分侧口腔试验，旨在评估注射用富血小板纤维蛋白（PRF）与曲安奈德（TA）治疗口腔扁平苔藓（OLP）的疗效。
本项随机分侧口腔试验纳入了 12 例双侧 OLP 病变且有症状的患者。将参与者随机分配到颊黏膜一侧接受 1ml 局部注射 PRF，对侧接受 0.5ml TA 注射。每周一次，共 4 周。采用视觉模拟评分（VAS）、REU 评分和病变面积评估疗效。
局部注射 TA 和 PRF 均能有效治疗口腔扁平苔藓。治疗 4 周后，VAS 评分平均降低（i-PRF 组为 68.5%，TA 组为 91%），REU 评分平均降低（i-PRF 组为 74%，TA 组为 91%）。两种治疗方法之间无统计学差异（p＞0.05）。
TA 局部注射在治疗 OLP 病变方面比 i-PRF 更有效。虽然 i-PRF 不能作为一线治疗选择，但它是一种无副作用的有前途的替代治疗选择。
