A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilova str., 119991, Moscow, Russia.
Chem Commun (Camb). 2022 Jun 9;58(47):6709-6712. doi: 10.1039/d2cc01648f.
Asymmetric cyclopropanation of alkenes by aryldiazoacetates was achieved using the readily-available racemic (diene)rhodium complex in combination with the chiral oxazoline-phenol ligand, which acts as the chiral poison and selectively inhibits one of the enantiomers of the catalyst. This approach eliminates a common problematic step of the synthesis of chiral catalysts.
使用易得的外消旋（二烯）铑配合物与手性恶唑啉-酚配体相结合，实现了芳基重氮乙酸酯对烯烃的不对称环丙烷化反应，后者作为手性毒物，选择性地抑制了催化剂的一个对映异构体。这种方法消除了手性催化剂合成中常见的一个有问题的步骤。
