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使用 LINX 增强食管括约肌。

Augmentation of the Esophageal Sphincter Using LINX.

机构信息

Department of Surgery, 417871Atrium Health Navicent, Macon GA, USA.

Internal Medicine and Community Medicine, 5225Mercer University School of Medicine, Macon GA, USA.

出版信息

Am Surg. 2022 Sep;88(9):2170-2175. doi: 10.1177/00031348221093800. Epub 2022 May 20.

Abstract

Gastroesophageal reflux disease (GERD) is the retrograde flow of gastric contents into the distal esophagus and may be treated medically or surgically. Magnetic sphincter augmentation surgery using LINX has recently demonstrated comparable results to Nissen fundoplication. We aimed to evaluate preoperative patient risk factors that were associated with LINX removal rates or postoperative EGD with dilation rates (POEGDD). This is a single institution retrospective review of patients undergoing LINX between 2015 and 2021. One hundred and twelve patients were reviewed, 106 included within the study; those excluded had prior foregut surgery or device fracture. Variables including age, sex, BMI, size of device, DeMeester score, manometry, GERD Health-Related Quality of Life (GERD HRQL) questionnaires, POEGDD, and removal rates were recorded. Comparing removal and dilation status, the chi-square or Fisher's exact test and the Mann-Whitney U test were used to analyze categorical and continuous variables, respectively. A < .05 was considered to be statistically significant. Eleven LINX devices were removed (10%); of these, 9 (81%) underwent POEGDD ( = .0023). There was no difference in DeMeester scores, size of device, or BMI in patients requiring LINX removal compared to those not removed or POEGDD rates. Patients who required LINX removal had higher GERD HRQL scores both preoperatively (median 34 vs 28) and postoperatively at all visits compared to those patients who did not undergo removal ( = .032). Manometry and DeMeester scores were not associated with LINX removal suggesting a less invasive GERD HRQL questionnaire may be a better predictor of patients who will succeed with LINX surgery.

摘要

胃食管反流病(GERD)是胃内容物逆流进入远端食管的一种疾病,可以通过药物或手术进行治疗。最近,使用 LINX 的磁括约肌增强手术已被证明与 Nissen 胃底折叠术具有相当的效果。我们旨在评估与 LINX 移除率或术后内镜下食管扩张术(POEGDD)相关的术前患者危险因素。这是一项对 2015 年至 2021 年期间接受 LINX 手术的患者进行的单中心回顾性研究。共对 112 例患者进行了回顾,其中 106 例患者被纳入研究;被排除的患者有先前的上消化道手术或设备断裂。记录了包括年龄、性别、BMI、设备大小、DeMeester 评分、测压、胃食管反流病健康相关生活质量(GERD HRQL)问卷、POEGDD 和移除率等变量。比较移除和扩张状态,使用卡方或 Fisher 确切检验和 Mann-Whitney U 检验分别分析分类和连续变量。认为 <.05 为统计学显著。11 个 LINX 设备被移除(10%);其中 9 个(81%)进行了 POEGDD( =.0023)。与未移除或 POEGDD 率相比,需要移除 LINX 的患者的 DeMeester 评分、设备大小或 BMI 没有差异。与未接受移除的患者相比,需要移除 LINX 的患者术前(中位数 34 对 28)和所有随访时的术后 GERD HRQL 评分均更高( =.032)。测压和 DeMeester 评分与 LINX 移除无关,这表明侵入性较小的 GERD HRQL 问卷可能是预测 LINX 手术成功患者的更好指标。

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