Department of Psychiatry, Faculty of Medicine, Saga University, Nabeshima 5-1-1, Saga, 849-8501, Japan.
Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi Higashi-ku 3-1-1, Fukuoka, 812-8582, Japan.
Psychiatry Res. 2022 Jul;313:114636. doi: 10.1016/j.psychres.2022.114636. Epub 2022 May 14.
Repetitive transcranial magnetic stimulation (rTMS) improves depressive symptoms in treatment-resistant depression (TRD). This study aimed to analyze changes in cerebrospinal fluid (CSF) metabolites in patients with TRD after rTMS. Five patients with TRD were enrolled in a high frequency (10-Hz) rTMS study. The concentration of 72 CSF metabolites were measured at baseline and at the end of the 6-week rTMS treatment. rTMS significantly increased CSF niacinamide, kynurenine, and creatinine levels and significantly decreased CSF cystine levels, but not the levels of the other 68 CSF metabolites. This is the first CSF metabolomics study on patients with TRD who underwent rTMS.
重复经颅磁刺激（rTMS）可改善治疗抵抗性抑郁症（TRD）患者的抑郁症状。本研究旨在分析 rTMS 治疗后 TRD 患者脑脊液（CSF）代谢物的变化。5 例 TRD 患者入组高频（10Hz）rTMS 研究。在基线和 6 周 rTMS 治疗结束时测量 72 种 CSF 代谢物的浓度。rTMS 显著增加 CSF 烟酰胺、犬尿氨酸和肌酸水平，显著降低 CSF 胱氨酸水平，但不影响其他 68 种 CSF 代谢物的水平。这是首个针对接受 rTMS 治疗的 TRD 患者进行的 CSF 代谢组学研究。
