Department of Psychiatry, Saga University Hospital, Nabeshima 5-1-1, Saga 849-8501, Japan.
Department of Psychiatry, Faculty of Medicine, Saga University, Nabeshima 5-1-1, Saga 849-8501, Japan.
Psychiatry Res. 2020 Jul;289:112995. doi: 10.1016/j.psychres.2020.112995. Epub 2020 Apr 16.
The impairment experienced by many individuals with depression is closely related to the cognitive symptoms of the disorder. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation method that provides a promising technique for improving cognitive symptoms in treatment-resistant depression (TRD). It has recently been demonstrated that TRD is associated with increased inflammatory process. In the present study, we investigated whether a relationship exists between changes in cognitive function and those in inflammatory cytokines before and after rTMS treatment. Eleven patients with TRD were enrolled in a high-frequency (10 Hz) rTMS study. Cognitive function, depressive symptoms and serum concentration of inflammatory cytokines (interleukin (IL)-1β, IL-6 and tumor necrosis factor-α) were measured at baseline and at the endpoint of rTMS treatment. rTMS treatment significantly improved depressive symptom scores and some subscales of cognitive dysfunction. The present study has demonstrated that partial changes in cognitive function and changes in IL-1β were significantly correlated. The partial improvement of cognitive dysfunction by rTMS in the present study might be attributable to the reduction of peripheral IL-1β levels. The present results should be replicated for verification in future studies.
许多抑郁症患者所经历的认知损伤与该疾病的认知症状密切相关。重复经颅磁刺激(rTMS)是一种非侵入性脑刺激方法，为改善治疗抵抗性抑郁症(TRD)的认知症状提供了一种很有前途的技术。最近有研究表明，TRD 与炎症过程增加有关。在本研究中，我们研究了 rTMS 治疗前后认知功能和炎症细胞因子变化之间是否存在关系。11 名 TRD 患者被纳入高频(10 Hz) rTMS 研究。在基线和 rTMS 治疗终点时测量认知功能、抑郁症状和血清炎症细胞因子浓度(白细胞介素(IL)-1β、IL-6 和肿瘤坏死因子-α)。rTMS 治疗显著改善了抑郁症状评分和认知功能障碍的一些子量表。本研究表明，认知功能的部分变化与 IL-1β 的变化显著相关。rTMS 对认知功能障碍的部分改善可能归因于外周 IL-1β 水平的降低。本研究结果应在未来研究中进行验证。
