Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China; Department of Developmental Cell Biology, Key Laboratory of Medical Cell Biology, China Medical University, Shenyang, Liaoning Province, China.
Department of Developmental Cell Biology, Key Laboratory of Medical Cell Biology, China Medical University, Shenyang, Liaoning Province, China.
Biomed Pharmacother. 2022 Jul;151:113099. doi: 10.1016/j.biopha.2022.113099. Epub 2022 May 17.
Neuroendocrine regulatory polypeptide VGF (nerve growth factor inducible) was firstly found in the rapid induction of nerve growth factor on PC12 cells. It was selectively distributed in neurons and many neuroendocrine tissues. This paper reviewed the latest literatures on the gene structure, transcriptional regulation, protein processing, distribution and potential receptors of VGF. The neuroendocrine roles of VGF and its derived polypeptides in regulating energy, water electrolyte balance, circadian rhythm and reproductive activities were also summarized. Furthermore, based on the experimental evidence in vivo and in vitro, dysregulation of VGF in different neuroendocrine diseases and the possible mechanism mediated by VGF polypeptides were discussed. We next discussed the potential as the clinical diagnosis and therapy for VGF related diseases in the future.
神经内分泌调节多肽 VGF（神经生长因子诱导）最初是在 PC12 细胞中神经生长因子的快速诱导中发现的。它选择性地分布在神经元和许多神经内分泌组织中。本文综述了 VGF 的基因结构、转录调控、蛋白加工、分布和潜在受体的最新文献。还总结了 VGF 及其衍生多肽在调节能量、水盐平衡、昼夜节律和生殖活动中的神经内分泌作用。此外，根据体内和体外的实验证据，讨论了 VGF 在不同神经内分泌疾病中的失调及其可能的 VGF 多肽介导的机制。接下来，我们讨论了 VGF 相关疾病未来作为临床诊断和治疗的潜力。
Zotero 插件