Sainte-Justine Hospital Research Centre, Montreal, Canada; Department of Psychiatry and Addictology, University of Montreal, Montreal, Canada.
Sainte-Justine Hospital Research Centre, Montreal, Canada; Department of Psychology, Concordia University, Montreal, Canada.
Neurosci Biobehav Rev. 2022 Jul;138:104688. doi: 10.1016/j.neubiorev.2022.104688. Epub 2022 May 17.
Obesity and eating disorders are conditions that involve eating behaviors and are sometimes comorbid. Current evidence supports alterations in immunoinflammatory processes in both obesity and eating disorders. A plausible hypothesis is that immunoinflammatory processes may be involved in the pathophysiology of obesity and eating disorders. The aim of this review is to highlight the link between obesity and eating disorders, with a particular focus on immunoinflammatory processes. First, the relation between obesity and eating disorders will be presented, followed by a brief review of the literature on their association with immunoinflammatory processes. Second, developmental factors will be discussed to clarify the link between obesity, eating disorders, and immunoinflammatory processes. Genetic and epigenetic risk factors as well as the potential roles of stress pathways and early life development will be presented. Finally, implications of these findings for future research are discussed. This review highlighted biological and developmental aspects that overlap between obesity and EDs, emphasizing the need for biopsychosocial research approaches to advance current knowledge and practice in these fields.
肥胖症和饮食失调是涉及饮食行为的病症，有时会并发。目前的证据支持肥胖症和饮食失调症中免疫炎症过程的改变。一个合理的假设是，免疫炎症过程可能与肥胖症和饮食失调症的病理生理学有关。本综述的目的是强调肥胖症和饮食失调症之间的联系，特别关注免疫炎症过程。首先，将介绍肥胖症和饮食失调症之间的关系，然后简要回顾文献中关于它们与免疫炎症过程的关联。其次，将讨论发育因素，以阐明肥胖症、饮食失调症和免疫炎症过程之间的联系。将介绍遗传和表观遗传风险因素以及应激途径和早期生活发展的潜在作用。最后，讨论了这些发现对未来研究的意义。本综述强调了肥胖症和 ED 之间重叠的生物学和发育方面，强调需要采用生物心理社会研究方法来推进这些领域的现有知识和实践。
