Center for Quantum Technology Research and Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements (MOE), School of Physics, Beijing Institute of Technology, Beijing 100081, China; Department of science, Taiyuan Institute of Technology, Taiyuan 030008, China.
Center for Quantum Technology Research and Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements (MOE), School of Physics, Beijing Institute of Technology, Beijing 100081, China.
Colloids Surf B Biointerfaces. 2022 Aug;216:112533. doi: 10.1016/j.colsurfb.2022.112533. Epub 2022 May 2.
Magnesium and its alloys have piqued the interest of researchers due to their promising mechanical properties and biocompatibility. Moreover, the excessively fast corrosion rate of Mg alloys impedes their development in biomedical fields. Inspired by conventional ion implantation, a less-toxic functional group (hydroxyl) is used as the ion source to bombard the ZK60 Mg alloy surface to form a functionalized oxide layer. The surface characterization, corrosion resistance, and biocompatibility are systematically investigated before and after hydroxyl ion implantation. A smoother surface mainly constituted of hydroxide/oxide is formed for the treated samples. The formed functionalized layer significantly improves the corrosion resistance of the ZK60 Mg alloy substrate and the proliferation of MC3T3-E1 cells, as demonstrated by electrochemical, immersion, and in vitro cytocompatibility tests. In summary, less-toxic functional ion implantation can be an effective strategy for preventing corrosion of Mg alloy implants and promoting their biocompatibility.
镁及其合金因其优异的机械性能和生物相容性而引起了研究人员的兴趣。然而，镁合金过快的腐蚀速率阻碍了其在生物医学领域的发展。受传统离子注入的启发，我们使用毒性更小的官能团（羟基）作为注入离子源来轰击 ZK60 镁合金表面，从而在其表面形成功能化氧化层。我们系统地研究了注入前后 ZK60 镁合金的表面特性、耐腐蚀性和生物相容性。经过羟基离子注入处理后，样品表面形成了更为平整的主要由氢氧化物/氧化物构成的层。电化学、浸泡和体外细胞相容性实验表明，所形成的功能化层显著提高了 ZK60 镁合金基体的耐腐蚀性和 MC3T3-E1 细胞的增殖能力。综上所述，毒性较小的官能团离子注入可以成为一种有效策略，用于防止镁合金植入物的腐蚀并提高其生物相容性。
