Department of Periodontics and Oral Medicine, Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University & Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxillofacial and Regenerative Medicine, Changsha 410008, China.
Department of Periodontics and Oral Medicine, Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University & Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxillofacial and Regenerative Medicine, Changsha 410008, China; Department of Oral Health Science, School of Dentistry, University of Washington, Seattle, WA 98195, USA.
Oral Oncol. 2022 Jul;130:105919. doi: 10.1016/j.oraloncology.2022.105919. Epub 2022 May 17.
Graft-versus-host disease (GVHD) is one of the most common and serious complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). About 45%∼83% of patients develop GVHD in the oral cavity. There has no medical records of oral submucous fibrosis (OSF) induced by GVHD after allo-HSCT, which should be brought to the attention of dentists.
移植物抗宿主病（GVHD）是异基因造血干细胞移植（allo-HSCT）后最常见和最严重的并发症之一。约 45%∼83%的患者会在口腔中发生 GVHD。allo-HSCT 后由 GVHD 引起的口腔黏膜下纤维化（OSF）在医学记录中尚无记载，这一点应该引起牙医的注意。
